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Titolo:
PRESENCE OF THE T-CELL ACTIVATION MARKER OX-40 ON TUMOR-INFILTRATING LYMPHOCYTES AND DRAINING LYMPH-NODE CELLS FROM PATIENTS WITH MELANOMA AND HEAD AND NECK CANCERS
Autore:
VETTO JT; LUM S; MORRIS A; SICOTTE M; DAVIS J; LEMON M; WEINBERG A;
Indirizzi:
OREGON HLTH SCI UNIV,DEPT SURG,SECT SURG ONCOL,PORTLAND VET AFFAIRS MED CTR,L223A PORTLAND OR 97201 EARLE A CHILES RES INST,PROVIDENCE PORTLAND MED CTR PORTLAND OR 00000
Titolo Testata:
The American journal of surgery
fascicolo: 3, volume: 174, anno: 1997,
pagine: 258 - 265
SICI:
0002-9610(1997)174:3<258:POTTAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NECROSIS-FACTOR; SPINAL-CORD; OX40 LIGAND; ANTIGEN; SYSTEM; RAT; SUBPOPULATIONS; IDENTIFICATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Vetto et al., "PRESENCE OF THE T-CELL ACTIVATION MARKER OX-40 ON TUMOR-INFILTRATING LYMPHOCYTES AND DRAINING LYMPH-NODE CELLS FROM PATIENTS WITH MELANOMA AND HEAD AND NECK CANCERS", The American journal of surgery, 174(3), 1997, pp. 258-265

Abstract

BACKGROUND: The OX-40 antigen is a cell surface glycoprotein in the tumor necrosis factor receptor family that is expressed primarily on activated CD4+ T cells, Selective target organ expression of the OX-40 receptor on autoantigen specific T cells has been found in autoimmune disease, In order to evaluate whether OX-40 is expressed on T cells from patients with nodal-draining carcinomas, OX-40 expression was assessed in tumor infiltrating lymphocytes (TILs), draining lymph node cells(DLNCs), and/or peripheral blood lymphocytes (PBLs) of 13 patients with head and neck squamous cell carcinomas and 9 patients with melanomas. METHODS: Cell phenotype was determined by fluorescence cell analysis using a monoclonal anti-body to human OX-40, and CD4+ T cell lymphokine production was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Expression of the OX-40 receptor was found in as many as 31% of the TILs and as many as 28% of the DLNCs tested, Conversely, no OX-40 expression was found in PBLs, In addition, CD4 T cells isolated from DLNCs (but not from TILs or PBLs) secreted a Th1 pattern of cytokines (IL-2, gamma interferon), Go-culture of autologous CD4+ TILs with an MHC class II+ melanoma cell line transfected with OX-40 ligand cDNA resulted in T cell proliferation and in vitro tumor regression, CONCLUSIONS: These findings suggest that OX-40+ CD4+ T cells isolated from tumors and their adjacent draining nodes may represent a tumor-specific population of activated T cells capable of mediating tumor reactivity, These cells may play an exploitable role in future trials of immunotherapy, (C) 1997 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:31:05