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Titolo:
IDENTIFICATION OF KAINATE RECEPTOR-MEDIATED INTRACELLULAR CALCIUM INCREASES IN CULTURED RAT CEREBELLAR GRANULE CELLS
Autore:
SAVIDGE JR; BLEAKMAN D; BRISTOW DR;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,DIV NEUROSCI,1-124 STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND LILLY RES CTR LTD WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Journal of neurochemistry
fascicolo: 4, volume: 69, anno: 1997,
pagine: 1763 - 1766
SICI:
0022-3042(1997)69:4<1763:IOKRIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE RECEPTORS; HIPPOCAMPAL-NEURONS; CONCANAVALIN-A; AMPA; CYCLOTHIAZIDE; ACID; EXPRESSION; ANTAGONISM; SUBUNIT; DESENSITIZATION;
Keywords:
CONCANAVALIN A; CYCLOTHIAZIDE; DESENSITIZATION; GLUTAMATE RECEPTOR GLUR5; LY300168; LY293558;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Savidge et al., "IDENTIFICATION OF KAINATE RECEPTOR-MEDIATED INTRACELLULAR CALCIUM INCREASES IN CULTURED RAT CEREBELLAR GRANULE CELLS", Journal of neurochemistry, 69(4), 1997, pp. 1763-1766

Abstract

The functional expression of the kainate subtype of glutamate receptor (GluR) has been investigated in cultured rat cerebellar granule cells using single cell intracellular calcium ([Ca2+](i)) measurements. Both AMPA- and kainate-induced [Ca2+](i) increases could be blocked completely by the AMPA receptor-selective antagonist LY300168 (50 mu M). However, following treatment with concanavalin A, an inhibitor of kainate receptor desensitisation, 30% of cells showed a kainate-induced [Ca2+](i) rise of >100 nM in the presence of LY300168. Responses to 30 muM kainate in the presence of LY300168 were virtually abolished by theAMPA and GluR5 kainate receptor competitive antagonist LY293558 (100 mu M). These results demonstrate the presence of functional kainate receptors on cultured cerebellar granule cells, and suggest that the GluR5 subtype of kainate receptor plays a significant role in kainate receptor mediated [Ca2+](i) increases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:26:57