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Titolo:
BENZODIAZEPINE RECEPTOR ANTAGONISTS - POSSIBLE USES IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS
Autore:
ABIDARGHAM A; CHARNEY DS; KRYSTAL JH;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,NEW YORK STATE PSYCHIAT INST,722 W 168TH ST,UNIT 28 NEW YORK NY 10032 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 00000
Titolo Testata:
CNS DRUGS
fascicolo: 3, volume: 8, anno: 1997,
pagine: 244 - 256
SICI:
1172-7047(1997)8:3<244:BRA-PU>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; IDIOPATHIC RECURRING STUPOR; OPERATED CHLORIDE CHANNELS; C-11 FLUMAZENIL KINETICS; COMPLEX PARTIAL SEIZURES; SACCADIC EYE-MOVEMENTS; TEMPORAL-LOBE EPILEPSY; HUMAN-BRAIN; PANIC DISORDER; HEPATIC-ENCEPHALOPATHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
147
Recensione:
Indirizzi per estratti:
Citazione:
A. Abidargham et al., "BENZODIAZEPINE RECEPTOR ANTAGONISTS - POSSIBLE USES IN THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS", CNS DRUGS, 8(3), 1997, pp. 244-256

Abstract

The receptor to which benzodiazepine hypnosedatives and anticonvulsants bind was discovered and characterised in the late 1970s, Agonists and inverse agonists that act at various sites within the receptor complex have been identified, In addition, antagonists of the benzodiazepine receptor have been synthesised, At present, flumazenil is the only agent of this class that is available clinically, Flumazenil has well documented benefits in the treatment of hepatic encephalopathy and benzodiazepine overdose, The drug has also been studied as a potential treatment for neuropsychiatric illnesses in which dysfunction of the gamma-aminobutyric acid (GABA)ergic system is implicated as a causal factor, Potential therapeutic benefits are suggested in benzodiazepine tolerance and withdrawal. benzodiazepine-related amnesia, epilepsy, sleepdisorders, cognitive disorders and idiopathic recurrent stupor. In contrast, no clear benefits have been found in alcoholism, anxiety and movement disorders. Flumazenil induces few adverse effects, and so represents a promising tool for pharmacological investigations of the GABAergic system and for imaging of the benzodiazepine receptor. As an imaging agent it has been used for quantification of the receptor, and asa neuronal marker in epilepsy and cerebral ischaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:05:55