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Titolo:
ENHANCED ENDOTHELIN-MEDIATED CORONARY VASOCONSTRICTION AND ATTENUATEDBASAL NITRIC-OXIDE ACTIVITY IN EXPERIMENTAL HYPERCHOLESTEROLEMIA
Autore:
MATHEW V; CANNAN CR; MILLER VM; BARBER DA; HASDAI D; SCHWARTZ RS; HOLMES DR; LERMAN A;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED ROCHESTER MN 55905
Titolo Testata:
Circulation
fascicolo: 6, volume: 96, anno: 1997,
pagine: 1930 - 1936
SICI:
0009-7322(1997)96:6<1930:EECVAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; L-ARGININE; RELAXING FACTOR; FLOW VELOCITY; ATHEROSCLEROSIS; ARTERIES; DYSFUNCTION; HUMANS; RABBIT; CELLS;
Keywords:
ENDOTHELIN; ENDOTHELIUM-DERIVED FACTORS; CIRCULATION; HYPERCHOLESTEROLEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
V. Mathew et al., "ENHANCED ENDOTHELIN-MEDIATED CORONARY VASOCONSTRICTION AND ATTENUATEDBASAL NITRIC-OXIDE ACTIVITY IN EXPERIMENTAL HYPERCHOLESTEROLEMIA", Circulation, 96(6), 1997, pp. 1930-1936

Abstract

Background Experimental hypercholesterolemia is associated with coronary vasomotor dysfunction. This study was designed to test the hypothesis that experimental hypercholesterolemia is characterized by alteredcoronary vasomotor responses to endothelin and inhibition of the endogenous NO pathway. Methods and Results Endothelin-l (ET-1) at 5 ng.kg(-1). min(-1) or N-G-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of nitric oxide synthase (NOS), at 50 mu g.kg(-1). min(-1) was infused into the left anterior descending coronary artery in pigs before and after 10 weeks of cholesterol diet. There was a significant increase in serum cholesterol. At 10 weeks, ET-1 resulted in an accentuated decrease in coronary blood flow (CBF) and coronary artery diameter (CAD) compared with baseline (-88 +/- 6% versus -45 +/- 9%, P < .O5, and -77 +/- 14% versus -18 +/- 8%, P < .05, respectively) and an increase in coronary vascular resistance (CVR) (242 +/- 18% versus 110 +/- 17%, P < .05); ET receptor density and binding affinity in epicardial coronary arteries were unchanged. The effect of L-NMMA on CBF, CAD, and CVR was attenuated at 10 weeks (-7 +/- 8% versus -48 +/- 4%, -2 +/- 3%versus -17 +/- 5%, and 16 +/- 10% versus 125 +/- 32%; each P < .05). Immunohistochemistry staining for constitutive NOS revealed a decreasein immunoreactivity in the coronary arteries of hypercholesterolemic pigs. Conclusions The present study demonstrates an enhanced coronary vasoconstrictive response to pathophysiological doses of endothelin and an attenuated response to the inhibition of endogenous NO activity, suggesting an alteration in coronary vascular reactivity in experimental hypercholesterolemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:27:39