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Titolo:
MAJOR DEPRESSIVE SUBTYPES AND TREATMENT RESPONSE
Autore:
FAVA M; UEBELACKER LA; ALPERT JE; NIERENBERG AA; PAVA JA; ROSENBAUM JF;
Indirizzi:
MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,DEPRESS RES PROGRAM,15 PARKMAN ST BOSTON MA 02114
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 42, anno: 1997,
pagine: 568 - 576
SICI:
0006-3223(1997)42:7<568:MDSATR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSONALITY-DISORDER; ANGER ATTACKS; FLUOXETINE TREATMENT; ATYPICAL DEPRESSION; DOUBLE-BLIND; ANXIOUS DEPRESSION; FOLLOW-UP; MELANCHOLIA; ANTIDEPRESSANTS; OUTPATIENTS;
Keywords:
MAJOR DEPRESSION; ATYPICAL DEPRESSION; MELANCHOLIC DEPRESSION; ANXIOUS DEPRESSION; SUBTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Fava et al., "MAJOR DEPRESSIVE SUBTYPES AND TREATMENT RESPONSE", Biological psychiatry, 42(7), 1997, pp. 568-576

Abstract

The purpose of this study was to investigate the relationships between depressive subtypes and response to fluoxetine treatment in a large cohort of outpatients. We studied 294 outpatients with major depressive disorder who were then treated with fluoxetine 20 mg/day for 8 weeks, Treatment outcome was evaluated with the Hamilton Depression Raring Scale (HDRS)-17, the Clinical Global Impressions-Severity, and with the HDRS-8; the latter is proposed to be a relatively more specific measure of depression severity than the HDRS-17, We assessed the relationships between degree of treatment response and several depressive subtypes (melancholic, atypical, hostile, and anxious depression, double depression, and depression with comorbid personality disorders), after adjusting for baseline depression severity. We found that nonanxious depressives (patients without any comorbid anxiety disorder) improved slightly but significantly more during treatment than anxious depressives on all outcome measures. Melancholic depression was associated with slightly less improvement on the HDRS-17 only, whereas the other subtypes of depression were not associated with differences in treatment outcome. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 02/04/20 alle ore 19:59:34