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Titolo:
RED KIDNEY BEAN LECTIN IS A POTENT CHOLECYSTOKININ RELEASING STIMULUSIN THE RAT INDUCING PANCREATIC GROWTH
Autore:
HERZIG KH; BARDOCZ S; GRANT G; NUSTEDE R; FOLSCH UR; PUSZTAI A;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,DEPT INTERNAL MED 1,SCHITTENHELMSTR 12 D-24105 KIEL GERMANY UNIV GOTTINGEN,DEPT SURG D-3400 GOTTINGEN GERMANY ROWETT RES INST BUCKSBURN AB2 9SB ABERDEEN SCOTLAND
Titolo Testata:
Gut
fascicolo: 3, volume: 41, anno: 1997,
pagine: 333 - 338
SICI:
0017-5749(1997)41:3<333:RKBLIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CCK RECEPTOR ANTAGONIST; PHASEOLUS-VULGARIS; SMALL-INTESTINE; GALLBLADDER CONTRACTION; INDUCED LESIONS; MUCOSAL GROWTH; INSULIN; PHYTOHEMAGGLUTININ; LOXIGLUMIDE; L-364,718;
Keywords:
PHYTOHEMAGGLUTININ; CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; PANCREATIC GROWTH; INTESTINAL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
K.H. Herzig et al., "RED KIDNEY BEAN LECTIN IS A POTENT CHOLECYSTOKININ RELEASING STIMULUSIN THE RAT INDUCING PANCREATIC GROWTH", Gut, 41(3), 1997, pp. 333-338

Abstract

Background-Lectins are proteins capable of specific binding to carbohydrates without altering their covalent structure. As an essential part of plants they are ingested in our daily diet. By binding to glycosyl side chains of receptors lectins can mimic or inhibit the action of the ligand. Oral administration of phytohaemagglutinin (PHH) in rats dose dependently induces growth of the small intestine and the pancreasby an unknown mechanism. Aims-To investigate the mechanism of PHA induced intestinal and pancreatic growth. Methods-Thirty day old male rats were pairfed for 10 days with lactalbumin as a control diet or lactalbumin plus PHA or purified soybean trypsin inhibitor (STI) as a positive control (42 mg/rat/day) with or without 20 mu g of the cholecystokinin A (CCK-A) antagonist MK 329. To investigate further the effect ofPHA on CCK release intestinal mucosal cells were isolated from rats which were continuously perfused in a perfusion apparatus. CCK release into the medium was assayed. Results-PHA and STI significantly stimulated growth of the pancreas and the small intestine. MK 329 blocked this growth effect in the pancreas but not in Germany the small intestine. In vivo, PHA significantly increased CCK plasma levels from 0.75 to 6.67 (SEM 2.23) compared with 2.3 (0.35) pM in the control group. In addition, in vitro PHA dose dependently stimulated CCK release with a maximal effect at 100 ng/ml. Conclusion-In vivo and in vitro PHA is a potent stimulus for CCK release in the rat, thereby inducing pancreaticgrowth, whereas intestinal growth is stimulated by a CCK independent mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:54:07