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Titolo:
EFFECT OF IBOTENATE LESIONS OF THE VENTROMEDIAL HYPOTHALAMUS ON THE WATER AND SALT INTAKE INDUCED BY ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN SODIUM-DEPLETED RATS
Autore:
DOVALE CF; CAMARGO GMPA; SAAD WA; MENANI JV; RENZI A; LUIZ AC; CERRI PS; CAMARGO LAA;
Indirizzi:
UNESP,PAULISTA STATE UNIV,DEPT PHYSIOL,1680 HUMAITA ST BR-14801903 ARARAQUARA BRAZIL UNESP,PAULISTA STATE UNIV,DEPT PHYSIOL BR-14801903 ARARAQUARA BRAZIL PAULISTA STATE UNIV,UNESP,SCH DENT,DEPT MORPHOL BR-14801903 ARARAQUARA BRAZIL
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 66, anno: 1997,
pagine: 19 - 25
SICI:
0165-1838(1997)66:1-2<19:EOILOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTALLY-INDUCED DRINKING; VENTRAL LAMINA TERMINALIS; LATERAL HYPOTHALAMUS; ANGIOTENSIN-II; ACID LESIONS; ADRENERGIC PATHWAYS; RENAL EXCRETION; BASAL FOREBRAIN; BLOOD-PRESSURE; RESPONSES;
Keywords:
SALT INGESTION; WATER INGESTION; ARTERIAL PRESSURE; ANGIOTENSIN II; ADRENERGIC AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Dovale et al., "EFFECT OF IBOTENATE LESIONS OF THE VENTROMEDIAL HYPOTHALAMUS ON THE WATER AND SALT INTAKE INDUCED BY ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN SODIUM-DEPLETED RATS", Journal of the autonomic nervous system, 66(1-2), 1997, pp. 19-25

Abstract

In this study we investigated the influence of a ventromedial hypothalamus (VMH) lesion with ibotenic acid on water and sodium intake and presser responses induced by combined treatment of the median preoptic nucleus (MnPO) with angiotensin Il (ANG II) and adrenergic agonists (phenylephrine, norepinephrine, isoproterenol and clonidine). Male Holtzman rats with a stainless steel cannula implanted into the MnPO and bilateral sham (vehicle) or VMH lesions with ibotenic acid were used. The ingestion of water and sodium and mean arterial pressure (MAP) were determined in separate groups submitted to sodium depletion with the diuretic furosemide (20 mg/rat). ANG II (10 pmol) injection into the MnPO of sham-lesioned rats induced water and sodium intake and presser responses. VMH-lesion reduced ANG II-induced water intake and increasedsaline intake, In sham rats phenylephrine (80 nmol) into MnPO increased, whereas norepinephrine (80 nmol) and clonidine (40 nmol) reduced ANG II-induced water intake while sodium intake was reduced only by clonidine into MnPO. In VMH-lesioned rats, phenylephrine reduced, noradrenaline increased and clonidine produced no effect on ANG II-induced water intake. In lesioned rats ANG II-induced sodium intake was reduced by phenylephrine and noradrenaline, whereas clonidine produced no change. ANG II-induced presser response was reduced in VMH-lesioned rats, but the presser response combining ANG II and phenylephrine or noradrenaline in VMH-lesioned rats was bigger than sham rats. These results show that the VMH is important for the changes in water and sodium intake and cardiovascular responses induced by angiotensinergic and adrenergic activation of the MnPO. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:57:44