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Titolo:
A NEW NATRIURETIC PEPTIDE ISOLATED FROM CARDIAC ATRIA OF TROUT, ONCORHYNCHUS-MYKISS
Autore:
TAKEI Y; FUKUZAWA A; ITAHARA Y; WATANABE TX; KUMAGAYE KY; NAKAJIMA K; YASUDA A; SMITH MP; DUFF DW; OLSON KR;
Indirizzi:
UNIV TOKYO,OCEAN RES INST,PHYSIOL LAB,1-15-1 MINAMIDAI TOKYO 164 JAPAN PEPTIDE INST INC,INST PROT RES MINO OSAKA 562 JAPAN SUNTORY INST BIOMED RES MISHIMA OSAKA 618 JAPAN UNIV NOTRE DAME,INDIANA UNIV SCH MED,S BEND CTR NOTRE DAME IN 46556 INDIANA UNIV S BEND IN 46565
Titolo Testata:
FEBS letters
fascicolo: 2, volume: 414, anno: 1997,
pagine: 377 - 380
SICI:
0014-5793(1997)414:2<377:ANNPIF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONING; VENTRICLES; EXPRESSION; PLASMA;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; VENTRICULAR NATRIURETIC PEPTIDE; MOLECULAR EVOLUTION; VASORELAXANT ACTIVITY; RAINBOW TROUT (ONCORHYNCHUS MYKISS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takei et al., "A NEW NATRIURETIC PEPTIDE ISOLATED FROM CARDIAC ATRIA OF TROUT, ONCORHYNCHUS-MYKISS", FEBS letters, 414(2), 1997, pp. 377-380

Abstract

Atrial and brain natriuretic peptides (ANP and BNP, respectively) aretwo cardiac natriuretic peptides (NPs) found in tetrapods from amphibians to mammals, whereas ANP and ventricular NP (VNP) have been identified in eel hearts, Because VNP has also been found in the rainbow trout ventricle, we attempted to isolate NP from trout cardiac atria in order to determine whether ANP and VNP are common cardiac NPs in teleosts, In the present experiments, we isolated VNP and a novel atrial NP consisting of 29 amino acid residues from the atria, This new trout NPexhibited similar sequence identity to mammalian ANP and BNP (50-60%). Its homology to eel ANP was low (52%) compared with high homology oftrout and eel VNP (78%). Based on yield, the content of this new NP in trout atria may be even smaller than that of VNP, The new trout atrial NP exhibited low relaxant activity in the chick rectum (only 1/10 of that of trout VNP), and extremely low vasorelaxant activity in the rat aortic strip (only 1/400 of that of human ANP), However, the new trout NP was equipotent with trout ANP and human ANP in relaxing trout epibranchial artery, Based on the sequence similarity with other NPs and on atrial content, the new NP isolated from trout atria cannot yet be assigned to a known member of the NP family. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:12:39