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Titolo:
MAINTENANCE OF NEUROEPITHELIAL PROGENITOR CELLS BY DELTA-NOTCH SIGNALING IN THE EMBRYONIC CHICK RETINA
Autore:
HENRIQUE D; HIRSINGER E; ADAM J; LEROUX I; POURQUIE O; ISHHOROWICZ D; LEWIS J;
Indirizzi:
IMPERIAL CANC RES FUND,44 LINCOLNS INN FIELDS,POB 123 LONDON WC2A 3PXENGLAND CNRS,INST EMBRYOL F-94736 NOGENT SUR MARNE FRANCE COLL FRANCE,INST EMBRYOL F-94736 NOGENT SUR MARNE FRANCE
Titolo Testata:
Current biology
fascicolo: 9, volume: 7, anno: 1997,
pagine: 661 - 670
SICI:
0960-9822(1997)7:9<661:MONPCB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA-NOTCH; RETROVIRAL VECTORS; XENOPUS EMBRYOS; GENE-EXPRESSION; HOMOLOG; NEUROGENESIS; FATE; DIFFERENTIATION; NEURONS; PATTERN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
D. Henrique et al., "MAINTENANCE OF NEUROEPITHELIAL PROGENITOR CELLS BY DELTA-NOTCH SIGNALING IN THE EMBRYONIC CHICK RETINA", Current biology, 7(9), 1997, pp. 661-670

Abstract

Background: Neurons of the vertebrate central nervous system (CNS) are generated sequentially over a prolonged period from dividing neuroepithelial progenitor cells. Some cells in the progenitor cell population continue to proliferate while others stop dividing and differentiateas neurons. The mechanism that maintains the balance between these two behaviours is not known, although previous work has implicated Delta-Notch signalling in the process. Results: In normal development, the proliferative layer of the neuroepithelium includes both nascent neurons that transiently express Delta-1 (Dl1), and progenitor cells that do not, Using retrovirus-mediated gene misexpression in the embryonic chick retina, we show that where progenitor cells are exposed to Dl1 signalling, they are prevented from embarking on neuronal differentiation, A converse effect is seen in cells expressing a dominant-negative form of Dl1, Dl1(dn), which we show renders expressing cells deaf to inhibitory signals from their neighbours, In a multicellular patch of neuroepithelium expressing Dl1(dn) essentially all progenitors stop dividing and differentiate prematurely as neurons, which can be of diversetypes. Thus, Delta-Notch signalling controls a cell's choice between remaining as a progenitor and differentiating as a neuron, Conclusions: Nascent retinal neurons, by expressing Dl1, deliver lateral inhibition to neighbouring progenitors; this signal is essential to prevent progenitors from entering the neuronal differentiation pathway, Lateral inhibition serves the key function of maintaining a balanced mixture of dividing progenitors and differentiating progeny, We propose that the same mechanism operates throughout the vertebrate CNS, enabling large numbers of neurons to be produced sequentially and adopt different characters ir response to a variety of signals. A similar mechanism of lateral inhibition, mediated by Delta and Notch proteins, may regulatestem-cell function in other tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:33:48