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Titolo:
EFFECTS OF DIRECT-CURRENT ON T-CELL ACTIVITY - MODULATION OF INTERLEUKIN-2 PRODUCTION
Autore:
HOLAN V; MACHALA O; DAO T; MINOWADA J;
Indirizzi:
ACAD SCI CZECH REPUBL,INST MOLEC GENET,FLEMINGOVO NAM 2 CR-16637 PRAGUE 6 CZECH REPUBLIC HAYASHIBARA BIOCHEM LABS INC,FUKJISAKI CELL CTR OKAYAMA JAPAN
Titolo Testata:
Immunobiology
fascicolo: 4-5, volume: 190, anno: 1994,
pagine: 368 - 375
SICI:
0171-2985(1994)190:4-5<368:EODOTA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-ALPHA; TUMOR-GROWTH; ENHANCEMENT; HAMSTERS; FIELDS; BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
V. Holan et al., "EFFECTS OF DIRECT-CURRENT ON T-CELL ACTIVITY - MODULATION OF INTERLEUKIN-2 PRODUCTION", Immunobiology, 190(4-5), 1994, pp. 368-375

Abstract

The production of interleukin-2 (IL-2) by mitogen-stimulated human peripheral blood leukocytes (PBL) was significantly enhanced by a short pretreatment of PBL with direct current (DC) at low intensities. Exposure of PBL to DC of 1 mA for more than 10 min resulted in inhibition of IL-2 production which correlated with decreased proliferation capacity of the treated cells. DC had similar enhancing and inhibitory effects on IL-2 production by the mitogen-stimulated human leukemia T cell line MOLT-13. However, DC itself did not stimulate IL-2 production in PBL or in MOLT-13 cells. In tare additional T cell lines tested, MOLT-16 and H-9, DC did not enhance mitogen-stimulated IL-2 production, butsuppressed it when applied at 1 mA for more than 10 min. Both the mitogen-stimulated and the interleukin-1 (IL-1)-enhanced IL-2 production were completely inhibited by 1 mA of DC applied for 20 min. The observed effects of DC mere due to a direct action of DC on the cells and not to possible effects of the secondary by-products of electrolysis. These results show that pretreatment of cells with DC can enhance or suppress IL-2 production depending on the intensity of DC and the type ofIL-2 producing cell clones.

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Documento generato il 27/11/20 alle ore 14:40:43