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Titolo:
ELECTROCHEMICAL AND ENZYMATIC OXIDATION OF GUANOSINE AND 8-HYDROXYGUANOSINE AND THE EFFECTS OF OXIDATION-PRODUCTS IN MICE
Autore:
GOYAL RN; JAIN N; GARG DK;
Indirizzi:
UNIV ROORKEE,DEPT CHEM ROORKEE 247667 UTTAR PRADESH INDIA
Titolo Testata:
Bioelectrochemistry and bioenergetics
fascicolo: 1, volume: 43, anno: 1997,
pagine: 105 - 114
SICI:
0302-4598(1997)43:1<105:EAEOOG>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURINE NUCLEOSIDE ANALOGS; CARBON-PASTE ELECTRODES;
Keywords:
GUANOSINE; 8-HYDROXYGUANOSINE; ELECTROOXIDATION; ENZYMATIC OXIDATION; TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Goyal et al., "ELECTROCHEMICAL AND ENZYMATIC OXIDATION OF GUANOSINE AND 8-HYDROXYGUANOSINE AND THE EFFECTS OF OXIDATION-PRODUCTS IN MICE", Bioelectrochemistry and bioenergetics, 43(1), 1997, pp. 105-114

Abstract

The electrochemical oxidation of guanosine and 8-hydroxyguanosine hasbeen studied in phosphate buffers at glassy carbon and pyrolytic graphite electrodes. On the basis of the electrochemical, spectroelectrochemical and product analysis, it has been concluded that oxidation of guanosine proceeds via the formation of 8-hydroxyguanosine. The initialelectrode reaction has been deduced to involve a 1e, 1H(+) step to give a free radical which on further oxidation gives 8-hydroxyguanosine. The 2e, 2H(+) oxidation of 8-hydroxyguanosine rapidly gives a diiminespecies which undergoes a series of chemical reactions to give urea riboside, 2-amino-4,5,6-trioxypyrimidine and a dimer at pH 3.0 and 5-guanidinohydantoin at pH 7.0. The peroxidase catalysed oxidation of 8-hydroxyguanosine was also found to proceed by a mechanism identical to electrochemical oxidation. Intracranial injection of a single dose of the oxidation product of guanosine (dimer) in albino mice caused nephritis with edema and hence was toxic in nature. (C) 1997 Elsevier Science S.A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:14:51