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Titolo:
A THEORETICAL-MODEL OF SOME SPATIAL AND TEMPORAL ASPECTS OF THE MITOCHONDRION CREATINE-KINASE MYOFIBRIL SYSTEM IN MUSCLE
Autore:
KEMP GJ; MANNERS DN; CLARK JF; BASTIN ME; RADDA GK;
Indirizzi:
ROYAL LIVERPOOL UNIV HOSP,DEPT ORTHOPAED & ACCID SURG,PRESCOT ST LIVERPOOL L69 3BX MERSEYSIDE ENGLAND OXFORD RADCLIFFE HOSP,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORDENGLAND UNIV OXFORD,DEPT BIOCHEM OXFORD OX1 3QU ENGLAND
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 174, anno: 1997,
pagine: 29 - 32
SICI:
0300-8177(1997)174:1-2<29:ATOSSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATP-ADP TRANSLOCASE; OXIDATIVE-PHOSPHORYLATION; PHOSPHOCREATINE SHUTTLE; OUTER-MEMBRANE; RESPIRATION; CELLS;
Keywords:
ADENINE NUCLEOTIDE TRANSLOCASE; CREATINE KINASE; DIFFUSION; MITOCHONDRION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Kemp et al., "A THEORETICAL-MODEL OF SOME SPATIAL AND TEMPORAL ASPECTS OF THE MITOCHONDRION CREATINE-KINASE MYOFIBRIL SYSTEM IN MUSCLE", Molecular and cellular biochemistry, 174(1-2), 1997, pp. 29-32

Abstract

We describe a model of mitochondrial regulation in vivo which takes account of spatial diffusion of high-energy (ATP and phosphocreatine) and low-energy metabolites (ADP and creatine), their interconversion bycreatine kinase (which is not assumed to be at equilibrium), and possible functional 'coupling' between the components of creatine kinase associated with the mitochondrial adenine nucleotide translocase and the myofibrillar ATPase. At high creatine kinase activity, the degree offunctional coupling at either the mitochondrial or ATPase end has little effect on relationships between oxidative ATP synthesis rate and spatially-averaged metabolite concentrations. However, lowering the creatine kinase activity raises the mean steady state ADP and creatine concentrations, to a degree which depends on the degree of coupling. At high creatine kinase activity, the fraction of flow carried by ATP is small. Lowering the creatine kinase activity raises this fraction, especially when there is little functional coupling. All metabolites showsmall spatial gradients, more so at low cytosolic creatine kinase activity, and unless there is near-complete coupling, so does net creatine kinase flux. During workjump transitions, spatial-average responses exhibit near-exponential kinetics as expected, while concentration changes start at the ATPase end and propagate towards the mitochondrion, damped in time and space.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:44:52