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Titolo:
CAN DOBUTAMINE ECHOCARDIOGRAPHY INDUCE MYOCARDIAL DAMAGE IN PATIENTS WITH DYSFUNCTIONAL BUT VIABLE MYOCARDIUM SUPPLIED BY A SEVERELY STENOTIC CORONARY-ARTERY
Autore:
MELUZIN J; TOMAN J; GROCH L; HORNACEK I; SITAR J; FISCHEROVA B; KARA T;
Indirizzi:
ST ANNA HOSP,INTERNAL DEPT 1,PEKARSKA 53 BRNO 65691 CZECH REPUBLIC
Titolo Testata:
International journal of cardiology
fascicolo: 2, volume: 61, anno: 1997,
pagine: 175 - 181
SICI:
0167-5273(1997)61:2<175:CDEIMD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-T; PROGNOSTIC VALUE; STRESS ECHOCARDIOGRAPHY; HIBERNATING MYOCARDIUM; INOTROPIC STIMULATION; DIAGNOSTIC EFFICIENCY; ISCHEMIC MYOCARDIUM; UNSTABLE ANGINA; CELL DAMAGE; RELEASE;
Keywords:
DOBUTAMINE; ECHOCARDIOGRAPHY; TROPONIN T; CORONARY ARTERY DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
J. Meluzin et al., "CAN DOBUTAMINE ECHOCARDIOGRAPHY INDUCE MYOCARDIAL DAMAGE IN PATIENTS WITH DYSFUNCTIONAL BUT VIABLE MYOCARDIUM SUPPLIED BY A SEVERELY STENOTIC CORONARY-ARTERY", International journal of cardiology, 61(2), 1997, pp. 175-181

Abstract

In animal experiments, dobutamine infusion was found to impair the oxygen supply-demand balance in hypoperfused areas of hibernating myocardium which may induce myocardial damage. The aim of our study was to assess whether dobutamine echocardiography can induce myocardial damagedetected by an increase in the cardiac troponin T level in blood. Twenty seven patients with coronary artery disease and severe stenosis ofat least one major coronary artery (greater than or equal to 90% of luminal diameter narrowing) supplying dysfunctional myocardial segmentsunderwent dobutamine echocardiography. Dobutamine was infused in 3 min dose increments of 5, 10, 20, 30, and 40 mu g per kg body weight perminute with the addition of atropine up to 1 mg if ischemia or an 85%predicted maximal heart rate were not achieved. In 15 patients the protocol with prolonged application of 40 mu g per kg per minute of dobutamine for 6 min and for the next 5 min with the addition of atropine was used. To exclude minor myocardial damage, an increase in the cardiac troponin T blood level was assessed qualitatively by the TROP T sensitive Rapid Test 20 h after dobutamine echocardiography. In 20 patients the dysfunctional segments were found to be viable with inducible ischemia exhibiting either continuous worsening in systolic thickening or ''biphasic'' response characterised by the improvement of their systolic thickening with a small dose and by a worsening of the thickening with a high dose of dobutamine. No patient exhibited positive TROP Tsensitive Rapid Test result. In patients with coronary artery diseaseand severe stenosis of a major coronary artery supplying dysfunctional but viable myocardial segments, dobutamine echocardiography does notinduce myocardial damage detectable by an increase in cardiac troponin T level. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:07:20