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Titolo:
MICROALBUMINURIA AND CAROTID-ARTERY INTIMA-MEDIA THICKNESS IN NONDIABETIC AND NIDDM SUBJECTS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY(IRAS)
Autore:
MYKKANEN L; ZACCARO DJ; OLEARY DH; HOWARD G; ROBBINS DC; HAFFNER SM;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV CLIN EPIDEMIOL,7703 FLOYD CURL DR SAN ANTONIO TX 78284 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 TUFTS UNIV NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111 PENN MED LAB,MEDLANTIC RES INST WASHINGTON DC 00000
Titolo Testata:
Stroke
fascicolo: 9, volume: 28, anno: 1997,
pagine: 1710 - 1716
SICI:
0039-2499(1997)28:9<1710:MACITI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; GLUCOSE-TOLERANCE TEST; WALL THICKNESS; ALBUMIN EXCRETION; MINIMAL MODEL; RISK-FACTORS; CARDIOVASCULAR HEALTH; HYPERTENSIVE PATIENTS; HEART-DISEASE; SENSITIVITY;
Keywords:
ATHEROSCLEROSIS; CAROTID ARTERIES; RISK FACTORS; MICROALBUMINURIA; ULTRASONICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
L. Mykkanen et al., "MICROALBUMINURIA AND CAROTID-ARTERY INTIMA-MEDIA THICKNESS IN NONDIABETIC AND NIDDM SUBJECTS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY(IRAS)", Stroke, 28(9), 1997, pp. 1710-1716

Abstract

Background and Purpose Microalbuminuria is associated with cardiovascular mortality in subjects with non-insulin-dependent diabetes mellitus (NIDDM). However, little is known about this association in nondiabetic subjects. Specifically, it is not known whether microalbuminuria is related to an early stage of atherosclerosis manifested as increasedintima media thickness (IMT) of carotid arteries. We investigated therelationship between microalbuminuria and carotid artery IMT in 991 nondiabetic and 450 NIDDM subjects aged 40 to 69 years. Methods Microalbuminuria was defined as albumin-to-creatinine ratio greater than or equal to 2 mg/mmol in a morning spot urine sample. B-mode ultrasound was used to assess the IMT of the common and internal carotid arteries. Results Altogether 13.9% of nondiabetic and 27.6% of NIDDM subjects had microalbuminuria, and 31.1% of nondiabetic and 50.8% of NIDDM subjects had hypertension. Subjects with microalbuminuria had greater commoncarotid artery (CCA) IMT than those without microalbuminuria (nondiabetic: 0.84+/-0.02 versus 0.80+/-0.01 mm, P=.010; NIDDM: 0.89+/-0.02 versus 0.86+/-0.01 mm, P=.152; combined: 0.86+/-0.01 versus 0.82+/-0.01. P=.005). The association of microalbuminuria and CCA IMT was independent of age, sex, ethnicity, smoking, and lipoprotein levels. Although further adjustment for hypertension in the multivariate linear regression analysis attenuated the difference in CCA IMT between subjects with and without microalbuminuria, this difference continued to be significant (combined: 0.86+/-0.01 versus 0.83+/-0.01 P=.015). In contrast to CCA IMT, microalbuminuria was not related to ICA IMT. Conclusions Microalbuminuria was associated with increased CCA IMT. This relationship was only partly mediated by hypertension. Thus, microalbuminuria is related to atherosclerosis at an early stage of the disease process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:51:41