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Titolo:
DOES THE ASSOCIATION OF RISK-FACTORS AND ATHEROSCLEROSIS CHANGE WITH AGE - AN ANALYSIS OF THE COMBINED ARIC AND CHS COHORTS
Autore:
HOWARD G; MANOLIO TA; BURKE GL; WOLFSON SK; OLEARY DH;
Indirizzi:
WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,MED CTR BLVD WINSTON SALEM NC 27157 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROL WINSTON SALEM NC 27157 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV PITTSBURGH,SCH MED,DEPT SURG PITTSBURGH PA 00000 UNIV PITTSBURGH,SCH MED,DEPT NEUROSURG PITTSBURGH PA 00000
Titolo Testata:
Stroke
fascicolo: 9, volume: 28, anno: 1997,
pagine: 1693 - 1701
SICI:
0039-2499(1997)28:9<1693:DTAORA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR HEALTH; DISEASE; HYPERTENSION; ARTERY;
Keywords:
ATHEROSCLEROSIS; AGING; CIGARETTE SMOKING; CAROTID ARTERIES; ULTRASONICS; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
G. Howard et al., "DOES THE ASSOCIATION OF RISK-FACTORS AND ATHEROSCLEROSIS CHANGE WITH AGE - AN ANALYSIS OF THE COMBINED ARIC AND CHS COHORTS", Stroke, 28(9), 1997, pp. 1693-1701

Abstract

Introduction A decrease in the estimated relative risk of cerebrovascular and cardiovascular diseases associated with known disease risk factors has been observed among elderly cohorts, perhaps suggesting thatcontinued risk factor management in the elderly may not be as efficacious as with younger age groups. In this paper, the differential magnitude of the association of risk factors with atherosclerosis across the age spectrum from 45 years to older than 75 years is presented. Methods Subclinical atherosclerosis as measured by carotid ultrasonographyand risk factor prevalence were assessed using similar methods among participants aged 45 to 64 years in the Atherosclerosis Risk in Communities (ARIC) study and among participants 65 years and older in the Cardiovascular Health Study (CHS). Pooling these two cohorts provided data on the relationship of risk factors and atherosclerosis on nearly 19 000 participants over a broad age range. Regression analyses were used to assess the consistency of the magnitude of the association of risk factors with atherosclerosis across the age spectrum separately forblack and white participants in cross-sectional analyses. Results As expected, each of the risk factors was globally (across all ages) associated with increased atherosclerosis. However, the magnitude of the association did not differ across the age spectrum for hypertension, low density lipoprotein cholesterol (LDL-c), fibrinogen, or body mass index (BMI). For whites, there was a significantly greater impact of smoking and HDL-C among older age strata but a smaller impact of diabetes. For black women, the impact of HDL-C decreased among the older age strata. Conclusions These data suggest that most risk factors continue to be associated with increased atherosclerosis at older ages, possibly suggesting a continued value in investigation of strategies to reduce atherosclerosis by controlling risk factors at older ages.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:17:40