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Titolo:
REPRODUCTIVE TOXICITY OF 2-BROMOPROPANE IN SPRAGUE-DAWLEY RATS
Autore:
YU IJ; CHUNG YH; LIM CH; MAENG SH; LEE JY; KIM HY; LEE SJ; KIM CH; KIM TG; LIM CH; PARK JS; MOON YH;
Indirizzi:
IND CHEM RES CTR,104-8 MOONJI DONG TAEJON 305380 SOUTH KOREA KOREA IND SAFETY CORP,IND HLTH RES INST,DEPT IND TOXICOL INCHON SOUTHKOREA
Titolo Testata:
Scandinavian journal of work, environment & health
fascicolo: 4, volume: 23, anno: 1997,
pagine: 281 - 288
SICI:
0355-3140(1997)23:4<281:RTO2IS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
F344 MALE-RAT; 1,2-DIBROMO-3-CHLOROPROPANE; DBCP;
Keywords:
ANEMIA; AZOOSPERMIA; EPIDIDYMIS; HEMATOPOIETIC TOXICITY; ISOPROPYL BROMIDE; LEUKOPENIA; OLIGOSPERMIA; TESTIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I.J. Yu et al., "REPRODUCTIVE TOXICITY OF 2-BROMOPROPANE IN SPRAGUE-DAWLEY RATS", Scandinavian journal of work, environment & health, 23(4), 1997, pp. 281-288

Abstract

Objectives In an effort to clarify the mass intoxication of workers at an electronic company in Korea, the possible causative chemical for reproductive toxicity, 2-bromopropane (2BP), was investigated. Methods2BP was tested through the use of repeated dose experiments among male Sprague Dawley rats. Ten rats were assigned to each treatment group. Vehicle control olive oil and 2BP concentrations of 125 mg/kg, 250 mg/kg, and 500 mg/kg were injected into the intraperitoneum on 28 consecutive days. Results The rats showed significant decreases in body weight depending on the 2BP dose. The right and left testes showed typicalweight loss depending on the dose of 2BP. The red blood cells, hemoglobin, and hematocrit showed some degree of decline with the high dose. The amount of hemoglobin, the mean platelet volume, the number of white blood cells, and the number of lymphocytes decreased significantly with the high dose, while the number of granulocytes and monocytes hada tendency to decrease depending on the dose of 2BP. The histopathology of the testes treated with the middle and high 2BP dose showed a typical patch appearance with severely depleted atrophic tubules, exhibiting germ cell necrosis of spermatogonia and spermatocytes in the seminiferous tubules. Leydig cell hyperplasia or hypertrophy in the interstitial tissue was also noticeable. The epididymis showed some degree of atrophy with vacuolization of the epididymal epithelium. ConclusionsThe testes are the main target organs tested for 2BP toxicity. 2BP also affect the hematopoietic system and thus induces leukopenia and normocytic anemia. Besides the reproductive organs and the hematopoietic system, no significant toxicity has been found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:12:15