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Titolo:
THE IMPACT OF MICROEMBOLI DURING CARDIOPULMONARY BYPASS ON NEUROPSYCHOLOGICAL FUNCTIONING
Autore:
PUGSLEY W; KLINGER L; PASCHALIS C; TREASURE T; HARRISON M; NEWMAN S;
Indirizzi:
UNIV COLL LONDON,MIDDLESEX HOSP,SCH MED,DEPT PSYCHIAT,MORTIMER ST LONDON W1N 8AA ENGLAND UNIV COLL LONDON,MIDDLESEX HOSP,SCH MED,DEPT PSYCHIAT LONDON W1N 8AA ENGLAND UNIV COLL LONDON,MIDDLESEX HOSP,SCH MED,DEPT CARDIAC SURG LONDON ENGLAND UNIV COLL LONDON,MIDDLESEX HOSP,SCH MED,DEPT NEUROL STUDIES LONDON ENGLAND
Titolo Testata:
Stroke
fascicolo: 7, volume: 25, anno: 1994,
pagine: 1393 - 1399
SICI:
0039-2499(1994)25:7<1393:TIOMDC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY BYPASS; MIDDLE CEREBRAL-ARTERY; TRANSCRANIAL DOPPLER; CAROTID ENDARTERECTOMY; BUBBLE OXYGENATORS; CONSEQUENCES; SURGERY; EMBOLI; FILTRATION; ULTRASOUND;
Keywords:
EMBOLISM; CARDIOPULMONARY BYPASS; NEUROPSYCHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W. Pugsley et al., "THE IMPACT OF MICROEMBOLI DURING CARDIOPULMONARY BYPASS ON NEUROPSYCHOLOGICAL FUNCTIONING", Stroke, 25(7), 1994, pp. 1393-1399

Abstract

Background and Purpose Microemboli have been implicated in the etiology of neuropsychological deficits after cardiopulmonary bypass. This study examined the incidence of high-intensity transcranial signals (microemboli) and their relation to changes in neuropsychological performance after surgery. Methods Transcranial Doppler ultrasonography was used to measure middle cerebral artery blood flow velocity and detect microemboli. The number of high-intensity transcranial signals was determined and related to a neurological examination and absolute changes in neuropsychological performance as well as the number of patients considered to exhibit a neuropsychological deficit. Data were available on 100 consenting patients undergoing routine cardiopulmonary bypass. Fifty of the patients were randomly assigned to a procedure that included a 40-mu m arterial line filter, and 50 had the procedure without any arterial line filter. Results Significantly more patients were found to have neuropsychological deficits in the group without the arterial line filter at both 8 days (P<.05) and 8 weeks (P<.03) after surgery. In addition, more ''soft'' neurological signs were found in the nonfiltered group 24 hours after surgery (P<.05). More high-intensity transcranial signals were found in the nonfiltered group, and the number of high-intensity transcranial signals was found to be related to the likelihood of a patient having a neuropsychological deficit at 8 weeks. Conclusions These data suggest that neuropsychological deficits afterroutine cardiopulmonary bypass are related to the number of microemboli delivered during surgery. Furthermore, the numbers of microemboli may be reduced by including a 40-mu m filter on the arterial line.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:36:51