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Titolo:
EFFECT OF INTRAVENOUS DEFIBROTIDE ON HEMORHEOLOGIC PARAMETERS IN PATIENTS WITH VASCULAR ATHEROSCLEROTIC DISEASE
Autore:
CAIMI G; LOPRESTI R; MONTANA M; CANINO B; GRIFO G; FRANCAVILLA G; SARNO A;
Indirizzi:
UNIV PALERMO,INST CLIN MED & CARDIOVASC DIS,VIA LEONARDO DA VINCI 52 I-90145 PALERMO ITALY
Titolo Testata:
Advances in therapy
fascicolo: 3, volume: 11, anno: 1994,
pagine: 139 - 143
SICI:
0741-238X(1994)11:3<139:EOIDOH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Keywords:
DEFIBROTIDE; VASCULAR ATHEROSCLEROTIC DISEASE; BLOOD RHEOLOGY; ERYTHROCYTE-MEMBRANE MICRORHEOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
G. Caimi et al., "EFFECT OF INTRAVENOUS DEFIBROTIDE ON HEMORHEOLOGIC PARAMETERS IN PATIENTS WITH VASCULAR ATHEROSCLEROTIC DISEASE", Advances in therapy, 11(3), 1994, pp. 139-143

Abstract

A study was carried out in 10 patients with vascular atherosclerotic disease to investigate the effects of a single 800-mg dose of defibrotide, given by intravenous infusion, on parameters reflecting red bloodcell (RBC)-membrane dynamic properties. At baseline and 60 minutes postinfusion, measurements were made of whole-blood filterability and aggregation, as well as RBC membrane fluidity and protein lateral mobility. Significant increases were noted in whole-blood filterability and RBC membrane fluidity following defibrotide. The results suggest that this molecule influences the hemorheologic pattern of the RBC membrane.

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Documento generato il 27/09/20 alle ore 21:33:46