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Titolo:
SAFETY OF AUTOLOGOUS, EX-VIVO EXPANDED HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-SPECIFIC CYTOTOXIC T-LYMPHOCYTE INFUSION IN HIV-INFECTED PATIENTS
Autore:
LIEBERMAN J; SKOLNIK PR; PARKERSON GR; FABRY JA; LANDRY B; BETHEL J; KAGAN J; ATKINS MB; GRADON J; STEIN D; VIRANIKETTER N; BANACH M; SCOTT M; MEYERS J; LEE E; STANDIFORD H; FONG DM; WANG A; BEYER D;
Indirizzi:
HARVARD UNIV,SCH MED,CTR BLOOD RES,800 HUNTINGTON AVE BOSTON MA 02115 TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL & ONCOL BOSTON MA02111 WESTAT CORP ROCKVILLE MD 00000 NIAID ROCKVILLE MD 00000
Titolo Testata:
Blood
fascicolo: 6, volume: 90, anno: 1997,
pagine: 2196 - 2206
SICI:
0006-4971(1997)90:6<2196:SOAEEH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD; CELL CLONES; SEROPOSITIVE INDIVIDUALS; ADOPTIVE IMMUNOTHERAPY; DISEASE PROGRESSION; TYPE-1 INFECTION; AIDS VIRUS; RESPONSES; MICE; INTERLEUKIN-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J. Lieberman et al., "SAFETY OF AUTOLOGOUS, EX-VIVO EXPANDED HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-SPECIFIC CYTOTOXIC T-LYMPHOCYTE INFUSION IN HIV-INFECTED PATIENTS", Blood, 90(6), 1997, pp. 2196-2206

Abstract

We infused six human immunodeficiency virus (HIV)-seropositive subjects with autologous CD8(+) cytotoxic T cells (CTLs) enriched for HIV-specific cytotoxicity targeted against a diversity of HIV epitopes in gp120, gag p17 and p24, and nef. There was no toxicity and no subject deteriorated clinically, In the first 2 weeks, CD4 counts increased for all subjects and plasma viremia decreased in five of six subjects. Twenty-four weeks later, the mean values of all measures of viral burden and surrogate markers of HIV infection were either unchanged or improved, but none of the changes was statistically significant. Two subjects continued to have decreased cell-associated viral burden and anothersubject had more than doubled CD4 cell count, HIV-specific CTL activity increased in most subjects, The increase in CD4 T-cell counts in the first weeks after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role in CD4 T-cell decline. The lack of any acute toxicity or adverse effect on viral burden suggests that therapy with antiviral CTLs deserves further study. (C) 1997by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:18:40