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Titolo:
A BCR-ABL(P190) FUSION GENE MADE BY HOMOLOGOUS RECOMBINATION CAUSES B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS IN CHIMERIC MICE WITH INDEPENDENCEOF THE ENDOGENOUS BCR PRODUCT
Autore:
CASTELLANOS A; PINTADO B; WERUAGA E; AREVALO R; LOPEZ A; ORFAO A; SANCHEZGARCIA I;
Indirizzi:
INST MICROBIOL BIOQUIM,DEPT PROLIFERAC & DIFERENCIAC CELULAR,EDIFICIODEPT,AVDA CAMPO CHARRO S-N SALAMANCA 37007 SPAIN INST MICROBIOL BIOQUIM,DEPT PROLIFERAC & DIFERENCIAC CELULAR,EDIFICIODEPT SALAMANCA 37007 SPAIN CTR INVEST & TECNOL,AREA REPROD ANIM MADRID SPAIN UNIV SALAMANCA,DEPT BIOL CELULAR & PATOL E-37008 SALAMANCA SPAIN UNIV SALAMANCA,SERV CITOMETRIA E-37008 SALAMANCA SPAIN
Titolo Testata:
Blood
fascicolo: 6, volume: 90, anno: 1997,
pagine: 2168 - 2174
SICI:
0006-4971(1997)90:6<2168:ABFGMB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; TYROSINE KINASE-ACTIVITY; BCR/ABL TRANSGENIC MICE; C-ABL PROTEIN; PHILADELPHIA-CHROMOSOME; V-ABL; PRO-B; ONCOGENE; EXPRESSION; TRANSCRIPT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A. Castellanos et al., "A BCR-ABL(P190) FUSION GENE MADE BY HOMOLOGOUS RECOMBINATION CAUSES B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS IN CHIMERIC MICE WITH INDEPENDENCEOF THE ENDOGENOUS BCR PRODUCT", Blood, 90(6), 1997, pp. 2168-2174

Abstract

BCR-ABL(p190) oncogene is the result of a reciprocal translocation between chromosomes 9 and 22 and is associated with B-cell acute lymphoblastic leukemia (B-ALL) in humans. Current models expressing the BCR-ABL(p190) chimeric gene fail to consistently reproduce the phenotype with which the fusion gene is associated in human pathology, mainly due to the difficulty of being expressed in the appropriate cell type in vivo. We have used here homologous recombination in ES cells to create an in-frame fusion of BCR-ABL(p190) that mimics the consequences of the human chromosomal translocation by fusion of BCR-ABL coding sequences into the bcr endogenous gene, The chimeric mice generated with the mutant embryonic stem cells systematically develop B-ALL. Using these chimeric mice, we further show that BCR-ABL oncogene does not require the endogenous bcr product in leukemogenesis, Our results show that BCR-ABL(p190) chimeric mice are a new model to study the biology of the BCR-ABL oncogene and indicate the efficacy of this strategy for studying the role of specific chromosome abnormalities in tumor development. (C) 1997 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 05:21:56