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Titolo:
QUANTITATIVE MEASUREMENTS OF REGIONAL CEREBRAL BLOOD-VOLUME USING MRIIN RATS - EFFECTS OF ARTERIAL CARBON-DIOXIDE TENSION AND MANNITOL
Autore:
LIN WL; PACZYNSKI RP; KUPPUSAMY K; HSU CY; HAACKE EM;
Indirizzi:
WASHINGTON UNIV,MALLINCKRODT INST RADIOL,510 S KINGSHIGHWAY ST LOUIS MO 63110 WASHINGTON UNIV,DEPT NEUROL ST LOUIS MO 63110
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 3, volume: 38, anno: 1997,
pagine: 420 - 428
SICI:
0740-3194(1997)38:3<420:QMORCB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEAN TRANSIT TIME; FLOW; HEMODYNAMICS; DISEASE; DOGS; QUANTIFICATION; ANGIOGRAPHY; CIRCULATION; ISCHEMIA; INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
W.L. Lin et al., "QUANTITATIVE MEASUREMENTS OF REGIONAL CEREBRAL BLOOD-VOLUME USING MRIIN RATS - EFFECTS OF ARTERIAL CARBON-DIOXIDE TENSION AND MANNITOL", Magnetic resonance in medicine, 38(3), 1997, pp. 420-428

Abstract

A three-dimensional (3D) T-1-weighted sequence was used to acquire high spatial resolution whole brain images in rats before and after the injection of an intravascular contrast agent, These T-1-weighted images were used to estimate regional cerebral blood volume (rCBV) as a percentage of blood volume in each voxel. Ventilation was manipulated to investigate the effects of altered arterial carbon dioxide tension (PaCO2) on rCBV. In addition, different doses of a hypertonic mannitol solution were used to investigate the sensitivity of the proposed methodin a serial monitoring paradigm. An rCBV of 2.40% +/- 0.34% was obtained before any physiological manipulation, in good agreement with literature values using alternative techniques. Using this method, it was found that there exists a linear relationship between PaCO2 and rCBV (R-2 = 0.77) and that rCBV increased in a dose and time dependent fashion in mannitol-treated rats, High signal-to-noise was available due tothe substantial increase in blood signal from the intravascular contrast agent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:02:23