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Titolo:
SPECIES-SPECIFIC ALTERATION OF HEPATIC GLUCOSE-6-PHOSPHATE-DEHYDROGENASE ACTIVITY WITH COPLANAR POLYCHLORINATED BIPHENYL - EVIDENCE FOR AN AH-RECEPTOR-LINKED MECHANISM
Autore:
HORI M; KONDO H; ARIYOSHI N; YAMADA H; OGURI K;
Indirizzi:
KYUSHU UNIV 62,FAC PHARMACEUT SCI,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 81282 JAPAN KYUSHU UNIV 62,FAC PHARMACEUT SCI,HIGASHI KU FUKUOKA 81282 JAPAN
Titolo Testata:
Chemosphere
fascicolo: 5, volume: 35, anno: 1997,
pagine: 951 - 958
SICI:
0045-6535(1997)35:5<951:SAOHG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; TRANSCRIPTIONAL REGULATION; RAT-LIVER; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; MOUSE; CELLS; EXPRESSION; TOXICITY; GENE; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN;
Keywords:
GLUCOSE 6-PHOSPHATE DEHYDROGENASE; ENZYME INDUCTION; 3,3',4,4',5-PENTACHLOROBIPHENYL (PCB 126); ARYLHYDROCARBON RECEPTOR; C57BL MICE; DBA MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M. Hori et al., "SPECIES-SPECIFIC ALTERATION OF HEPATIC GLUCOSE-6-PHOSPHATE-DEHYDROGENASE ACTIVITY WITH COPLANAR POLYCHLORINATED BIPHENYL - EVIDENCE FOR AN AH-RECEPTOR-LINKED MECHANISM", Chemosphere, 35(5), 1997, pp. 951-958

Abstract

We examined the in vivo effect of a highly toxic coplanar polychlorinated biphenyl (PCB) on the hepatic activity of glucose 6-phosphate dehydrogenase (G6PDH) in aryl hydrocarbon (Ah)-responsive (C57/BL) and -less-responsive (DBA) strains of mice. The activity in the C57BL strainwas moderately increased by 3,3',4,4',5-pentachlorobiphenyl (PCB 126)in a dose dependent manner. However, this was not observed in DBA mice although greater doses were injected. 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) with a non-planar structure did not increase G6PDH activity, The increase in G6PDH activity with PCB 126 was also seen in rats, butnot in guinea pigs. The activity in the latter species was decreased rather than increased. These results suggest that the induction of hepatic G6PDH by coplanar PCB is mediated by a mechanism involving the Ahreceptor, and the response was highly species-specific. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:23:49