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Titolo:
ORIGIN, EXPRESSION AND POSSIBLE FUNCTIONS OF THE 2 ALTERNATIVELY SPLICED FORMS OF THE MOUSE NEDD2 MESSENGER-RNA
Autore:
KUMAR S; KINOSHITA M; DORSTYN L; NODA M;
Indirizzi:
INST MED & VET SCI,HANSON CTR CANC RES,POB 14,RUNDLE MALL ADELAIDE SA5000 AUSTRALIA KYOTO UNIV,SCH MED,DEPT MOL ONCOL KYOTO 606 JAPAN
Titolo Testata:
Cell death and differentiation
fascicolo: 5, volume: 4, anno: 1997,
pagine: 378 - 387
SICI:
1350-9047(1997)4:5<378:OEAPFO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; ICE-LIKE PROTEASES; DEATH GENE CED-3; CELL-DEATH; CYSTEINE PROTEASE; IL-1-BETA-CONVERTING ENZYME; ICE/CED-3 PROTEASE; MICE DEFICIENT; LAMIN-A; APOPTOSIS;
Keywords:
ICE; CED-3; ICH-1; CASPASES; APOPTOSIS; PROTEASE ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
S. Kumar et al., "ORIGIN, EXPRESSION AND POSSIBLE FUNCTIONS OF THE 2 ALTERNATIVELY SPLICED FORMS OF THE MOUSE NEDD2 MESSENGER-RNA", Cell death and differentiation, 4(5), 1997, pp. 378-387

Abstract

The Nedd2 gene, a member of the ICE/ced-3 family, transcribes two mRNA species by differential splicing. One of these encodes a shorter truncated version of the protein termed Nedd2s/ICH-1s. While Nedd2/ICH-1 induces apoptosis, ICH-1s was proposed to be a negative regulator of cell death. In this communication we have analyzed various aspects of the Nedd2s/ICH-1s. The coding region of mouse Nedd2 consists of 10 exons and alternative splicing of the 7th exon results in the generation of two transcripts. Although Nedd2s expression conferred partial resistance to serum withdrawal-induced apoptosis in NIH-3T3 cells, it failedto prevent cell death induced by the overexpression of Nedd2 and was unable to suppress apoptosis in two other cell lines (N18 and FDC-P1) under factor deprived conditions. Our results indicate that Nedd2s/ICH-1s is not a general modulator of cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:46:45