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Titolo:
TUMOR TYPE AND VASCULARITY - IMPORTANT VARIABLES IN INFUSIONAL BRACHYTHERAPY WITH COLLOIDAL P-32
Autore:
NGUYEN H; GHANEM G; MORANDINI R; VERBIST A; LARSIMONT D; FALLAIS C; FRUHLING J; VANHOUTTE P;
Indirizzi:
INST JULES BORDET,DEPT RADIAT ONCOL & NUCL MED,1 RUE HEGER BORDET B-1000 BRUSSELS BELGIUM MALLINCKRODT MED INC,DEPT RADIAT ONCOL & NUCL MED BRUSSELS BELGIUM MALLINCKRODT MED INC,LAB ONCOL & EXPT SURG BRUSSELS BELGIUM MALLINCKRODT MED INC,DEPT PATHOL BRUSSELS BELGIUM FREE UNIV BRUSSELS,INST JULES BORDET,CTR TUMEURS BRUSSELS BELGIUM
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 2, volume: 39, anno: 1997,
pagine: 481 - 487
SICI:
0360-3016(1997)39:2<481:TTAV-I>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT-MELANOMA; RADIATION MODALITY; FRACTION SIZE; RADIOSENSITIVITY; CANCER;
Keywords:
INFUSIONAL BRACHYTHERAPY; COLLOIDAL P-32; VASCULAR DENSITY; TUMOR UPTAKE; BREMSSTRAHLUNG IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
H. Nguyen et al., "TUMOR TYPE AND VASCULARITY - IMPORTANT VARIABLES IN INFUSIONAL BRACHYTHERAPY WITH COLLOIDAL P-32", International journal of radiation oncology, biology, physics, 39(2), 1997, pp. 481-487

Abstract

Purpose: This study investigated the role of histologic tumor characteristics, in comparison with a normal tissue, and of tumor vascularization on the uptake and retention of colloidal P-32 used in infusional brachytherapy of solid cancers. The cytotoxicity of colloidal P-32 wasalso evaluated for two tumors of different radiosensitivity, a melanoma, and a squamous cell carcinoma. Methods and Materials: An in vitro analysis of colloidal P-32 uptake was carried out on a human melanoma cell line, HBL, a human squamous cell carcinoma, SCC1, and normal fibroblasts, F-NBB. Tumor retention of colloidal P-32 was Studied in vivo for the HBL and the SCC1 tumors implanted subcutaneously in nude mice. Tumor vascular density was determined by microscopic study of Masson's trichrome slides of HBL and SCC1 tumors of about 1 cm diameter. Results: In vitro studies showed that the time required for maximal cell uptake of colloidal P-32 was only 10-20 min for the SCC1 and HBL tumors, while it took at least 60 min for the fibroblasts. After intratumoral injection of macroaggregated albumin (MAA), followed by 50 mu Ci of colloidal P-32, Bremsstrahlung imaging performed at 6 and 24 h shelvedthat the activity remained in the HBL tumor while some of the radiocolloids leaked from the SCC1 tumor and was trapped in the reticuloendothelial system of the liver. Organ activity counting confirmed this finding: P-32 activity was three to four times higher in the HBL than in the SCC1 tumor, whereas the activity in the liver, insignificant in the HBL mice (less than 0.1 mu Ci/g), was as high as 24 mu Ci/g in the SCC1 mice. This phenomenon may be explained by the difference in tumor vascular density, estimated for the HBL to be about four times less than that of the SCC1 tumor (5.7 vs. 21.4 blood vessels per mm(2) for the HBL and the SCC1 tumors, respectively), Conclusion: Intratumoral infusion of colloidal P-32 may be a useful complement of radiation therapy in the treatment of nonresectable but accessible solid tumors. Tumorvascularization must be taken into account for a successful vascular blockade by MAA prior to the infusion of colloidal P-32. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:09:28