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Titolo:
EXPRESSION OF BMP-2 AND TGF-BETA-1 MESSENGER-RNA DURING HEALING OF THE RABBIT MANDIBLE
Autore:
SI SH; JIN Y; YANG LJ; TIPOE GL; WHITE FH;
Indirizzi:
FOURTH MIL MED UNIV,STOMATOL COLL,DEPT ORAL PATHOL XIAN 710032 SHAANXI PEOPLES R CHINA FOURTH MIL MED UNIV,STOMATOL COLL,DEPT ORAL PATHOL XIAN 710032 SHAANXI PEOPLES R CHINA UNIV HONG KONG,DEPT ANAT HONG KONG HONG KONG
Titolo Testata:
European journal of oral sciences
fascicolo: 4, volume: 105, anno: 1997,
pagine: 325 - 330
SICI:
0909-8836(1997)105:4<325:EOBATM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-2; GROWTH-FACTOR-BETA; INSITU HYBRIDIZATION; DIFFERENTIATION PATHWAY; FRACTURE REPAIR; MESSENGER-RNA; SUPERFAMILY; OSTEOBLASTS; MEMBERS; TISSUES;
Keywords:
BONE MORPHOGENETIC PROTEIN-2; TRANSFORMING GROWTH FACTOR-BETA-1; FRACTURE HEALING; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Si et al., "EXPRESSION OF BMP-2 AND TGF-BETA-1 MESSENGER-RNA DURING HEALING OF THE RABBIT MANDIBLE", European journal of oral sciences, 105(4), 1997, pp. 325-330

Abstract

To identify the cell types which produce BMP and TGF-beta during fracture healing and to elucidate the interactions between BMP and TGF-beta in regulating cell proliferation and differentiation at various stages, an experimental model of fracture healing in the rabbit mandible was established and the expression of BMP-2 and TGF-beta 1 mRNA was studied at different healing stages by in situ hybridization. The resultsshowed that undifferentiated mesenchymal cells, differentiating osteoblasts and chondroblasts, had higher levels of BMP-2 mRNA at the stageof intramembranous bone formation and early chondrogenesis, while thelevel of TGF-beta 1 mRNA was higher in chondrocytes and active differentiated osteoblasts during chondrogenesis and endochondral ossification, respectively. We conclude that BMP-2 expression was correlated with the differentiation of mesenchymal cells into osteoblasts and chondrocytes. TGF-beta 1 mRNA expression was closely associated with the active synthetic stage of osteoblasts and chondrocytes. These observations suggest that both BMP and TGF-beta are involved in the regulation offracture healing. BMP may play an important role in bone induction and early chondrogenesis, while TGF-beta regulates the proliferation andactive synthetic ability of chondrocytes and osteoblasts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:23:11