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Titolo:
AGE-RELATED DECLINE OF AUDITORY FUNCTION IN THE CHINCHILLA (CHINCHILLA-LANIGER)
Autore:
MCFADDEN SL; CAMPO P; QUARANTA N; HENDERSON D;
Indirizzi:
SUNY BUFFALO,CTR HEARING & DEAFNESS,HEARING RES LAB,DEPT COMMUN DISORDERS,215 PARKER HALL BUFFALO NY 14214 INRS,SERV PHYSIOL ENVIRONM F-54501 VANDOEUVRE NANCY FRANCE UNIV BARI,DEPT AUDIOL & OTOL BARI ITALY
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 111, anno: 1997,
pagine: 114 - 126
SICI:
0378-5955(1997)111:1-2<114:ADOAFI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORINEURAL HEARING-LOSS; PRODUCT OTOACOUSTIC EMISSIONS; INFERIOR COLLICULUS NEURONS; HAIR CELL LOSS; C57BL/6J MICE; CBA/J MICE; AZIMUTHAL LOCATION; EVOKED POTENTIALS; MONGOLIAN GERBIL; COCHLEAR NUCLEUS;
Keywords:
PRESBYCUSIS; AGE-RELATED HEARING LOSS; AUDITORY EVOKED POTENTIAL; DISTORTION PRODUCT OTOACOUSTIC EMISSION; COCHLEAR PATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Mcfadden et al., "AGE-RELATED DECLINE OF AUDITORY FUNCTION IN THE CHINCHILLA (CHINCHILLA-LANIGER)", Hearing research, 111(1-2), 1997, pp. 114-126

Abstract

The aim of this study was to examine the functional consequences of aging in the chinchilla, a rodent with a relatively long life span and a range of hearing similar to that of humans. Subjects were 21 chinchillas aged 10-15 years, and 23 young controls. Thresholds were determined from auditory evoked potentials (EVPs), and outer hair cell (OHC) functioning was assessed by measuring 2f(1)-f(2) distortion product otoacoustic emissions (DPOAEs). Six cochleas from 11-12-year-old animals were examined for hair cell loss and gross strial pathology. The results show that the chinchilla exhibits a small but significant decline of auditory sensitivity and OHC functioning between 3 and 15 years of age, with high-frequency losses exceeding and growing more rapidly thanlow-frequency losses. Compared to rodents with shorter life spans, the chinchilla has a rate of loss that is more similar to that of humans, which could make it a valuable model for understanding the etiology of human presbycusis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:17:21