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Titolo:
A MISLEADING DIAGNOSIS OF HYPERSENSITIVITY PNEUMONITIS IN A PATIENT SUFFERING FROM AN ASPERGILLUS INFECTION AND AUTOSOMAL CHRONIC GRANULOMATOUS-DISEASE (CGD) - JUST ONE EXAMPLE OF A DIAGNOSTIC TRAP TYPICAL FORTHIS KIND OF CGD
Autore:
RAEDER E; FREIHORST J; RINGE H; ROSENWOLFF A; VONDERHARDT H; GAHR M; ROESLER J;
Indirizzi:
UNIVKLINIKUM CARL GUSTAV CARUS,KLIN & POLIKLIN KINDERHEILKUNDE,FETSCHERSTR 74 D-01307 DRESDEN GERMANY HANNOVER MED SCH,KINDERKLIN HANNOVER GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 8, volume: 145, anno: 1997,
pagine: 810 - 814
SICI:
0026-9298(1997)145:8<810:AMDOHP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
GER
Keywords:
AUTOSOMAL CGD; P47PHOX DEFICIENCY; PSEUDOGENE; HYPERSENSITIVITY; PNEUMONITIS; ASPERGILLUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
E. Raeder et al., "A MISLEADING DIAGNOSIS OF HYPERSENSITIVITY PNEUMONITIS IN A PATIENT SUFFERING FROM AN ASPERGILLUS INFECTION AND AUTOSOMAL CHRONIC GRANULOMATOUS-DISEASE (CGD) - JUST ONE EXAMPLE OF A DIAGNOSTIC TRAP TYPICAL FORTHIS KIND OF CGD", Monatsschrift fur Kinderheilkunde, 145(8), 1997, pp. 810-814

Abstract

Chronic granulomatous disease (CGD) is caused by the inability of phagocytes to kill ingested germs by microbicidal reactive oxygen. Especially forms of CGD with retained ability to produce some reactive oxygen sometimes tend to imitate other diseases. An 8-year-old girl with a normal history presented with many symptoms matching those of hypersensitivity pneumonitis like restrictive ventilation disorder, suggestivechest x-ray, a majority of CD8 positive lymphocytes in the broncho-alveolar-lavage fluid (BAL), suggestive histological valuation. Hints for the true underlying disease like neutrophilia and a high anti-Aspergillus-titer could be overlooked easily. The patient was treated with steroids and antibiotics because an infection could not be excluded. The CGD had not been recognised at this time, however. After a significant improvement for a short time the patient experienced a dramatic respiratory deterioration. A lot of Aspergillus could now be found in theBAL. Finally the patient died because of an ARDS and respiratory insufficiency even though signs of the Aspergillus infection improved significantly. Discussion: Whenever CGD must be considered appropriate diagnostics have to be performed-especially before treatment with steroids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:04:24