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Titolo:
GLYCOSYLATION OF SILYBIN
Autore:
KREN V; KUBISCH J; SEDMERA P; HALADA P; PRIKRYLOVA V; JEGOROV A; CVAK L; GEBHARDT R; ULRICHOVA J; SIMANEK V;
Indirizzi:
ACAD SCI CZECH REPUBL,INST MICROBIOL,VIDENSKA 1083 CZ-14220 PRAGUE 4 CZECH REPUBLIC GALENA PHARMACEUT CZ-74770 OPAVA CZECH REPUBLIC UNIV TUBINGEN,INST PHYSIOL CHEM D-72076 TUBINGEN GERMANY PALACKY UNIV,INST MED CHEM CZ-77515 OLOMOUC CZECH REPUBLIC
Titolo Testata:
Journal of the Chemical Society. Perkin transactions. I
fascicolo: 17, , anno: 1997,
pagine: 2467 - 2474
SICI:
0300-922X(1997):17<2467:GOS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIHEPATOTOXIC ACTIVITY; SILIBININ DIASTEREOMERS; SILYMARIN; PLASMA; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
V. Kren et al., "GLYCOSYLATION OF SILYBIN", Journal of the Chemical Society. Perkin transactions. I, (17), 1997, pp. 2467-2474

Abstract

Silybin glycosides-23-O-beta-glucoside 2b, beta-galactoside 3b, beta-lactoside 4b and beta-maltoside 5b-have been synthesized by different methods (Helferich glycosylation, Lewis acid catalysis), Separation oftwo silybin diastereoisomers in the form of acetylated monoglycosideshas been achieved for the first time, These new silybin glycosides are 4-30 times more water-soluble, and their hepatoprotectivity is increased compared with that of the parent compound silybin 1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:47:04