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Titolo:
THE ROLE OF VIROLOGICAL AND IMMUNOLOGICAL FACTORS IN MOTHER-TO-CHILD TRANSMISSION OF HIV-1
Autore:
COLOGNESI C; HALAPI E; JANSSON M; HODARA V; STEUER G; TRESOLDI E; LEITNER T; SCARLATTI G;
Indirizzi:
SAN RAFFAELE SCI INST,DIBIT,UNIT IMMUNOBIOL HIV,VIA OLGETTINA 58 I-20132 MILAN ITALY SAN RAFFAELE SCI INST,DIBIT,UNIT IMMUNOBIOL HIV I-20132 MILAN ITALY KAROLINSKA INST,MICROBIOL & TUMORBIOL CTR S-10401 STOCKHOLM SWEDEN
Titolo Testata:
American journal of reproductive immunology [1989]
fascicolo: 3, volume: 38, anno: 1997,
pagine: 197 - 200
SICI:
1046-7408(1997)38:3<197:TROVAI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTION; RECEPTOR; PROGRESSION; POPULATIONS; INDIVIDUALS; RESISTANCE; PHENOTYPE; INFANTS; CELLS;
Keywords:
HIV-1; MOTHER-TO-CHILD TRANSMISSION; VIRAL PHENOTYPE; NEUTRALIZING RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Colognesi et al., "THE ROLE OF VIROLOGICAL AND IMMUNOLOGICAL FACTORS IN MOTHER-TO-CHILD TRANSMISSION OF HIV-1", American journal of reproductive immunology [1989], 38(3), 1997, pp. 197-200

Abstract

PROBLEM: More than 90% of human immunodeficiency virus type 1 (HIV-1)infection in children is acquired by mother-to-child transmission. However, infection of the child occurs in between 14 and 35% of cases. METHOD OF STUDY: To understand the mechanisms involved in HN-I transmission, we have investigated the antigenic, molecular, and phenotypic characteristics of the virus harbored in infected mothers and their children. RESULTS: A clear correlation was observed between the transmission of the virus and the isolation of viral variants with a rapidly replicating and syncytium-inducing phenotype from the mother. Furthermore, non-transmitting mothers were able to neutralize several primary isolates more frequently than transmitting mothers. The comparison of theviral phenotype and genotype of mother-child pairs showed that the transmitted virus did not have common features, suggesting that transmission is usually not a selective process. CONCLUSIONS: This study suggests that transmission is governed by an interaction of both viral and immunological factors. The results obtained indicate that different strategies can be applied for the prevention of transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:26:19