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Titolo:
ROLE OF CURDLAN SULFATE IN THE BINDING OF HIV-1 GP120 TO CD4 MOLECULES AND THE PRODUCTION OF GP120-MEDIATED TNF-ALPHA
Autore:
TAKEDAHIROKAWA N; NEOH LP; AKIMOTO H; KANEKO H; HISHIKAWA T; SEKIGAWA I; HASHIMOTO H; HIROSE S; MURAKAMI T; YAMAMOTO N; MIMURA T; KANEKO Y;
Indirizzi:
JUNTENDO UNIV,IZUNAGAOKA HOSP,DEPT MED,1129 NAGAOKA,IZUNAGAOKA CHO SHIZUOKA 41022 JAPAN JUNTENDO UNIV,IZUNAGAOKA HOSP,DEPT MED SHIZUOKA 41022 JAPAN JUNTENDO UNIV,SCH MED,DEPT RHEUMATOL & INTERNAL MED,BUNKYO KU TOKYO 113 JAPAN AJINOMOTO CO INC,CHUO KU TOKYO 104 JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT MICROBIOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Microbiology and immunology
fascicolo: 9, volume: 41, anno: 1997,
pagine: 741 - 745
SICI:
0385-5600(1997)41:9<741:ROCSIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR-NECROSIS-FACTOR; ENVELOPE GLYCOPROTEIN GP120; RECOMBINANT SOLUBLE CD4; T-CELLS; DEXTRAN SULFATE; INFECTION; INVITRO; INHIBITION; AIDS;
Keywords:
HIV-1 GP120; CURDLAN SULFATE; TNF-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
N. Takedahirokawa et al., "ROLE OF CURDLAN SULFATE IN THE BINDING OF HIV-1 GP120 TO CD4 MOLECULES AND THE PRODUCTION OF GP120-MEDIATED TNF-ALPHA", Microbiology and immunology, 41(9), 1997, pp. 741-745

Abstract

To clarify the mechanism by which curdlan sulfate (CRDS) inhibits human immunodeficiency virus (HIV)-1 infection, we examined its influenceon the binding of gp120 to CD4 molecules on T cells and macrophages, as well as on the production of TNF-alpha by gp120-stimulated macrophages (which promotes HIV-1 replication). CRDS treatment of cells not only inhibited the binding of HIV-1 gp120 to CD4(+) cells, but also inhibited TNF-alpha production induced by gp120. Inhibition of HIV-1 infection by CRDS may be related to these two actions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:08:52