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Titolo:
INTERFERON-ALPHA AND INTERFERON-GAMMA DIFFERENTIALLY REDUCE RAPID IMMATURE T-CELL DEATH BY CONTACT WITH HIV-1 CARRIER CELL CLONES IN-VITRO
Autore:
KINZL P; OTANI T; BENZ R; MINOWADA J;
Indirizzi:
HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR,675-1 FUJISAKI OKAYAMA702 JAPAN HAYASHIBARA BIOCHEM LABS INC,FUJISAKI CELL CTR OKAYAMA 702 JAPAN UNIV WURZBURG,DEPT BIOTECHNOL D-97074 WURZBURG GERMANY
Titolo Testata:
Microbiology and immunology
fascicolo: 9, volume: 41, anno: 1997,
pagine: 709 - 716
SICI:
0385-5600(1997)41:9<709:IAIDRR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTED-CELLS; LYMPHOCYTES; REPLICATION; DISEASE; APOPTOSIS; INVITRO; LINES; BETA; CD4+;
Keywords:
T-CELL DEATH; CYTOTOXIC HIV-1 CELLS; IFN EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Kinzl et al., "INTERFERON-ALPHA AND INTERFERON-GAMMA DIFFERENTIALLY REDUCE RAPID IMMATURE T-CELL DEATH BY CONTACT WITH HIV-1 CARRIER CELL CLONES IN-VITRO", Microbiology and immunology, 41(9), 1997, pp. 709-716

Abstract

The non-antigen specific rapid cytotoxic (CT) death of immature TdT(+)CD4(+)CD8(+) T cells due to contact with HIV-1 carrier T-cell clones we have found recently is a novel phenomenon, The effects of interferons (IFN) on this CT reaction were studied in vitro, Treatment of the HIV-1 carrier clones, referred to as ''effectors,'' with IFN-alpha but not IFN-gamma, or of the susceptible immature TdT(+)CD4(+)CD8(+) T cells, referred to as ''targets,'' with IFN-gamma but not IFN-alpha, for 24 hr prior to CT testing was found to reduce the CT reaction, Simultaneously, a down-regulated CD8 expression and an up-regulated antigen expression of both major histocompatibility antigen complex class I (MHC-I) and HIV-1 gp120/gp160 in the IFN-alpha treated effector (gp120(+)CD8(+) HPB-ALL/HIV), and/or simultaneously up-regulated antigen expression of both CD8 and MHC-I in the IFN-gamma treated target (CD3(+)CD8() HPB-ALL) were found to be associated with reduced CT reaction, However, altered antigen expression in the IFN-gamma treated effecters or IFN-alpha treated targets did not affect the ultimate degree of CT reaction, This study thus suggests a possible therapeutic efficacy of IFNby reducing the direct elimination of the T-cell precursors in HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 05:53:19