Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHANGES IN THE IMMUNOPHENOTYPE OF RECURRENT PITUITARY-ADENOMAS
Autore:
MINDERMANN T; KOVACS K; WILSON CB;
Indirizzi:
EDITORIAL OFF,DEPT NEUROL SURG,1360 9TH AVE,SUITE 210 SAN FRANCISCO CA 94122 UNIV CALIF SAN FRANCISCO,SCH MED,DEPT NEUROL SURG SAN FRANCISCO CA 94143 UNIV TORONTO,ST MICHAELS HOSP,DEPT PATHOL TORONTO M5B 1W8 ON CANADA
Titolo Testata:
Neurosurgery
fascicolo: 1, volume: 35, anno: 1994,
pagine: 39 - 44
SICI:
0148-396X(1994)35:1<39:CITIOR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE PRODUCTION; APOPLEXY;
Keywords:
IMMUNOPHENOTYPE; PITUITARY ADENOMAS; RECURRENCE RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T. Mindermann et al., "CHANGES IN THE IMMUNOPHENOTYPE OF RECURRENT PITUITARY-ADENOMAS", Neurosurgery, 35(1), 1994, pp. 39-44

Abstract

Only two cases have been reported of a pituitary adenoma that changedphenotype between its initial resection and recurrence. To determine the frequency of such cases among our patients, we examined the clinical course of these tumors and characterized any patterns. We reviewed the charts of 1023 patients with pituitary adenomas who underwent surgery between 1984 and 1992 at the University of California at San Francisco. Of the 65 patients (6.4%) who had operations for or clinical evidence of tumor recurrence, five (7.7%) had tumors that changed phenotype. The female-to-male ratio was 4:1, and age at the onset of symptomswas 33.2 +/- 15.3 years (mean +/- standard deviation). Changes occurred in hormone production and hormone release after 6.4 +/- 3.4 years. At some point, all five tumors were invasive and four were macroadenomas. Two patients had more than one operation for tumor recurrence; three had silent or symptomatic pituitary apoplexy; and three had undergone sellar irradiation before the changes in phenotype occurred. The behavior of these tumors therefore seems to be aggressive, We do not yetknow whether phenotypic changes in pituitary adenomas have any treatment implications. Therefore, we advocate the complete immunostaining of primary and recurrent pituitary adenomas so that additional data about their clinical course can be collected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 04:27:36