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Titolo:
THE STAPHYLOCOCCUS-AUREUS SCDA GENE - A NOVEL LOCUS THAT AFFECTS CELL-DIVISION AND MORPHOGENESIS
Autore:
BRUNSKILL EW; DEJONGE BLM; BAYLES KW;
Indirizzi:
UNIV IDAHO,DEPT MICROBIOL MOL BIOL & BIOCHEM MOSCOW ID 83844 UNIV IDAHO,DEPT MICROBIOL MOL BIOL & BIOCHEM MOSCOW ID 83844 ROCKEFELLER UNIV,MICROBIOL LAB NEW YORK NY 10021 UNIV MARYLAND BALTIMORE CTY,PROGRAM MOL & CELL BIOL BALTIMORE MD 21228
Titolo Testata:
Microbiology
, volume: 143, anno: 1997,
parte:, 9
pagine: 2877 - 2882
SICI:
1350-0872(1997)143:<2877:TSSG-A>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-N-ACETYLGLUCOSAMINIDASE; L-ALANINE AMIDASE; METHICILLIN RESISTANCE; SEQUENCE-ANALYSIS; IDENTIFICATION; PEPTIDOGLYCAN; TRANSFORMATION; AUTOLYSIS; STRAINS; FEMA;
Keywords:
STAPHYLOCOCCUS AUREUS; SCDA; PEPTIDOGLYCAN CROSS-LINKING; SEPTUM FORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.W. Brunskill et al., "THE STAPHYLOCOCCUS-AUREUS SCDA GENE - A NOVEL LOCUS THAT AFFECTS CELL-DIVISION AND MORPHOGENESIS", Microbiology, 143, 1997, pp. 2877-2882

Abstract

A new Staphylococcus aureus gene termed scdA was found upstream of the autolysis regulatory genes, lytS and lytR, and was shown to potentially encode a hydrophilic 25 kDa protein, Analysis of scdA transcription revealed that it is transcribed as a monocistronic message and is lytSR-independent, A role in cell wall metabolism was indicated by examination of the scdA mutant S. aureus KB323, which had a grossly aberrant cellular morphology and formed large cell clusters when grown in liquid culture medium, Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4, These data suggest that scdA plays an important role in staphylococcal cell division.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:11:56