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Titolo:
CARRIER-MEDIATED SYSTEM FOR PEFLOXACIN UPTAKE IN HUMAN MONOCYTES
Autore:
MEMIN E; PANTEIX G; REVOL A;
Indirizzi:
CTR HOSP LYON SUD,SERV BIOCHIM,SECTEUR J COURMONT,BATIMENT 3B F-69310PIERRE BENITE FRANCE INST PASTEUR,LAB MYCOBACTERIES F-69365 LYON 07 FRANCE
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 2, volume: 40, anno: 1997,
pagine: 263 - 268
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; MEMBRANE-VESICLES; PLASMA-MEMBRANE; CA UPTAKE; VERAPAMIL; MACROPHAGES; INHIBITION; RECEPTORS; TRANSPORT; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Memin et al., "CARRIER-MEDIATED SYSTEM FOR PEFLOXACIN UPTAKE IN HUMAN MONOCYTES", Journal of antimicrobial chemotherapy, 40(2), 1997, pp. 263-268

Abstract

Protein transporters present in cellular membranes can influence the intracellular concentration of a variety of drugs. Pefloxacin is a fluoroquinolone which is commonly used in systemic infections. Its transport mechanisms have never been described. In the present study, we demonstrated that pefloxacin uptake is carrier-mediated. Pefloxacin crosses the membrane in zwitterionic form. The transport seems to differ from that of other fluoroquinolones which use amino acid or organic anion transporters. Pefloxacin uptake is not influenced by the presence ofhexose in the incubation medium. It does not use a nucleoside transport system to penetrate the cells but adenosine increases the uptake. The carrier is inhibited by verapamil at 60 min and is activated by a Ca2+-dependent system.

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Documento generato il 01/12/20 alle ore 07:41:04