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Titolo:
DAILY EXERCISE ATTENUATES THE SYMPATHETIC-NERVE RESPONSE TO EXERCISE BY ENHANCING CARDIAC AFFERENTS
Autore:
DICARLO SE; STAHL LK; BISHOP VS;
Indirizzi:
NE OHIO UNIV,COLL MED,DEPT PHYSIOL,4209 STATE ROUTE 44,POB 95 ROOTSTOWN OH 44272 UNIV TEXAS,HLTH SCI CTR SAN ANTONIO TX 78284
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 42, anno: 1997,
pagine: 1606 - 1610
SICI:
0363-6135(1997)42:3<1606:DEATSR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOPULMONARY BAROREFLEX CONTROL; FOREARM VASCULAR-RESISTANCE; DYNAMIC EXERCISE; CAROTID BAROREFLEX; CONSCIOUS RABBITS; BLOOD-PRESSURE; HEART-RATE; REACTIVITY; HUMANS; MEN;
Keywords:
BAROREFLEX; CENTRAL COMMAND; SYMPATHOEXCITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Dicarlo et al., "DAILY EXERCISE ATTENUATES THE SYMPATHETIC-NERVE RESPONSE TO EXERCISE BY ENHANCING CARDIAC AFFERENTS", American journal of physiology. Heart and circulatory physiology, 42(3), 1997, pp. 1606-1610

Abstract

''Central command'' may initiate the sympathoexcitatory responses at the onset of exercise by shifting the operating point of the arterial baroreflex toward higher pressures. Daily exercise (DE) attenuates thesympathoexcitatory responses to submaximal exercise. This DE-induced adaptation may be due, in part, to an enhanced inhibitory influence ofcardiac afferents. This is suggested because cardiac afferents exert a tonic inhibitory influence on the arterial baroreflex which is enhanced by DE. Therefore, the influence of cardiac afferents on the regulation of renal sympathetic nerve activity (RSNA) during exercise was examined in a group of sedentary and age-matched DE rabbits. The rabbitswere instrumented with a Silastic catheter inserted into the pericardial sac, electrodes around the renal sympathetic nerves, and cathetersin the femoral artery and vein. In the sedentary rabbits, treadmill exercise (12 m/min, 20% grade) significantly increased mean arterial pressure (Delta 18 +/- 3 mmHg), heart rate (Delta 36 +/- 3 beats/min), and RSNA (Delta 295 +/- 23%). More importantly, cardiac afferent blockade (2% intrapericardial procainamide) did not significantly alter the RSNA response to exercise in the sedentary rabbits. DE did not alter the mean arterial pressure (Delta 15 +/- 1 mmHg) or heart rate (Delta 55 +/- 8 beats/min) response to exercise; however, RSNA (Delta 252 +/- 9%) was significantly reduced. In contrast to the sedentary rabbits, cardiac afferent blockade in the DE rabbits significantly increased theRSNA response to exercise (Delta 417 +/- 30%). These results suggest that DE attenuates the RSNA response to dynamic exercise due, in part,to an enhanced inhibitory influence of cardiac afferents.

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Documento generato il 03/12/20 alle ore 06:04:58