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Titolo:
HEAT-STRESS PROTECTS AGED HYPERTROPHIED AND NONHYPERTROPHIED RAT HEARTS AGAINST ISCHEMIC DAMAGE
Autore:
CORNELUSSEN RN; GARNIER AV; VORK MM; GEURTEN P; RENEMAN RS; VANDERVUSSE GJ; SNOECKX LHEH;
Indirizzi:
MAASTRICHT UNIV,CARDIOVASC RES INST MAASTRICHT,DEPT PHYSIOL,POB 616 NL-6200 MD MAASTRICHT NETHERLANDS MAASTRICHT UNIV,CARDIOVASC RES INST MAASTRICHT,DEPT PHYSIOL NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 42, anno: 1997,
pagine: 1333 - 1341
SICI:
0363-6135(1997)42:3<1333:HPAHAN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTISCHEMIC VENTRICULAR RECOVERY; GLOBAL-ISCHEMIA; SHOCK PROTEINS; INFARCT SIZE; RABBIT HEART; REPERFUSION; HYPERTHERMIA; EXPRESSION; RESISTANCE; INDUCTION;
Keywords:
CARDIAC HYPERTROPHY; CREATINE KINASE; LEFT VENTRICULAR FUNCTION; CORONARY FLOW; HEAT STRESS PROTEIN 70;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Cornelussen et al., "HEAT-STRESS PROTECTS AGED HYPERTROPHIED AND NONHYPERTROPHIED RAT HEARTS AGAINST ISCHEMIC DAMAGE", American journal of physiology. Heart and circulatory physiology, 42(3), 1997, pp. 1333-1341

Abstract

To explore the effects of heat stress (HS) in aged hypertrophied and nonhypertrophied rat hearts, postischemic recovery was investigated 15mo after aortic constriction (AoB) or sham operation (Sham). Twenty-four hours after HS (42 degrees C; 15 min) or control treatment (normothermia), global ischemia was induced for 20 min in isolated AoB heartsand for 20 or 30 min in Sham hearts. After HS, postischemic recovery after 20-min ischemia in AoB hearts and 30-min ischemia in Sham hearts, respectively, was significantly better than in corresponding controls. In AoB hearts, cardiac output (CO), left ventricular developed pressure (LVDP), and the positive maximal first derivative of left ventricular pressure (+dP/dt(max)) recovered to 33 +/- 26 (means +/- SD), 87 /- 5, and 72 +/- 12%, respectively, after HS and to 5 +/- 8, 22 +/- 39, and 17 +/- 29% of preischemic values, respectively, in controls. Postischemic arrhythmias were significantly reduced in HS hypertrophied hearts, but creatine kinase (CK) loss was not reduced. In Sham hearts subjected to 30 min ischemia, CO, LVDP, and +dP/dt(max) recovered to 20 +/- 20, 75 +/- 8, and 59 +/- 15%, respectively, after HS and to 3 +/- 8, 21 +/- 32, and 16 +/- 32% of preischemic values, respectively, incontrols. Duration of arrhythmias and CK loss were not reduced in theheated hearts. When Sham hearts were subjected to only 20-min ischemia, functional recovery was not different in HS and control hearts, indicating that HS pretreatment extends the ischemic interval before irreversible injury occurs in the heart. In all HS Sham hearts, the myocardial 72-kDa HS protein (HSP 70) content was significantly increased. However, in HS AoB hearts, HSP 70 levels were not significantly different from the values in the control hearts. These results indicate that HS pretreatment induces cardioprotection in aged hypertrophied and nonhypertrophied rat hearts, which, however, cannot be unequivocally related to increased HSP 70 tissue contents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:20:12