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Titolo:
MASSIVE UNCOMPLICATED VASCULAR IMMUNE-COMPLEX DEPOSITS IN THE KIDNEY OF A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
Autore:
TAKAZOE K; SHIMADA T; NAKANO H; KAWAMURA T; UTSUNOMIYA Y; KANAI T; KITAJIMA T; YAMAGUCHI Y; JOH K; MITARAI T; SAKAI O;
Indirizzi:
MONASH MED CTR,DEPT NEPHROL,246 CLAYTON RD CLAYTON VIC 3168 AUSTRALIA JIKEI UNIV,SCH MED,DEPT PATHOL,DEPT INTERNAL MED 2 TOKYO JAPAN SAITAMA CHILDRENS MED CTR,DEPT INTERNAL MED 4 SAITAMA JAPAN
Titolo Testata:
Clinical nephrology
fascicolo: 3, volume: 48, anno: 1997,
pagine: 195 - 198
SICI:
0301-0430(1997)48:3<195:MUVIDI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEPHRITIS; LESIONS;
Keywords:
LUPUS VASCULOPATHY; RENAL DYSFUNCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TUBULOINTERSTITIAL DAMAGE; VASCULAR IMMUNE COMPLEX DEPOSITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
K. Takazoe et al., "MASSIVE UNCOMPLICATED VASCULAR IMMUNE-COMPLEX DEPOSITS IN THE KIDNEY OF A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS", Clinical nephrology, 48(3), 1997, pp. 195-198

Abstract

The case of a patient with systemic lupus erythematosus (SLE) is reported which was accompanied by renal dysfunction and massive vascular immune deposits in the kidney without active glomerular lesions. The renal biopsy showed arterioles and small arteries with circumferential periodic acid-Schiff (PAS) and Masson trichrome-positive homogenous material in the subendothelial area in the absence of thrombotic, necrotizing or inflammatory lesions, Immunofluorescence and electron microscopy examination demonstrated immune deposits in the vascular walls. Glomeruli showed only minor abnormalities with a trend to collapse. Therewas no improvement in renal dysfunction over a 4-year period until the patient's death, despite steroid therapy producing a decrease in disease activity. The autopsy showed similar vascular changes to those seen in the biopsy, however; glomeruli were either sclerotic or showed atrend to collapse. Massive uncomplicated vascular immune complex deposition without active glomerular lesions is rare. The present case indicates that this type of lupus vasculopathy may be a prognostic factorfor the loss of renal function in SLE mediated by hemodynamic glomerular injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:46:43