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Titolo:
A NEUROTOXIN N-METHYL(R)SALSOLINOL INDUCES APOPTOTIC CELL-DEATH IN DIFFERENTIATED HUMAN DOPAMINERGIC NEUROBLASTOMA SH-SY5Y CELLS
Autore:
MARUYAMA W; BENEDETTI MS; TAKAHASHI T; NAOI M;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU,GOKISO CHO NAGOYA AICHI 466 JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU NAGOYA AICHI 466 JAPAN KONAN WOMENS COLL,DEPT FOOD & NUTR KONAN JAPAN ZAMBON GRP,PRECLIN DEV & HUMAN PHARMACOL,DIV RES & DEV MILAN ITALY NATL INST LONGEV SCI,DEPT BASIC GERONTOL,BIOCHEM & METAB LAB OBU 474 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 232, anno: 1997,
pagine: 147 - 150
SICI:
0304-3940(1997)232:3<147:ANNIAC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ION; RAT;
Keywords:
PARKINSONS DISEASE; N-METHYL(R)SALSOLINOL; APOPTOSIS; RETINOIC ACID; SH-SY5Y CELLS; OXIDATIVE STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
W. Maruyama et al., "A NEUROTOXIN N-METHYL(R)SALSOLINOL INDUCES APOPTOTIC CELL-DEATH IN DIFFERENTIATED HUMAN DOPAMINERGIC NEUROBLASTOMA SH-SY5Y CELLS", Neuroscience letters, 232(3), 1997, pp. 147-150

Abstract

In retinoic acid-differentiated SH-SY5Y cells an endogenous neurotoxin N-methyl(R)salsolinol induced apoptotic cell death. Using a single cell gel electrophoresis (comet) assay, DNA damage was quantitatively measured, and it was found to depend on the concentration of N-methyl(R)salsolinol and the incubation time up to 6 h. The differentiated cells were more sensitive to N-methyl(R)salsolinol than the undifferentiated cells. Radical scavengers protected the cells from DNA damage, indicating oxidative stress is involved in the apoptotic cell process. These results suggest that apoptosis induced by endogenous neurotoxins might be the mechanism of the cell death of dopamine neurons in Parkinson's disease. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:24:55