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Titolo:
ROLE OF ATP-SENSITIVE K-PIA, AN ADENOSINE A(1) RECEPTOR AGONIST( CHANNELS IN ANTINOCICEPTION INDUCED BY R)
Autore:
OCANA M; BAEYENS JM;
Indirizzi:
UNIV GRANADA,SCH MED,DEPT PHARMACOL E-18012 GRANADA SPAIN UNIV GRANADA,SCH MED,DEPT PHARMACOL E-18012 GRANADA SPAIN UNIV GRANADA,SCH MED,INST NEUROSCI E-18012 GRANADA SPAIN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 1, volume: 350, anno: 1994,
pagine: 57 - 62
SICI:
0028-1298(1994)350:1<57:ROAKAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADMINISTERED AMINOGLYCOSIDE ANTIBIOTICS; ACTIVATED POTASSIUM CURRENT; G-PROTEINS; MORPHINE ANALGESIA; CORONARY-ARTERY; RAT HIPPOCAMPUS; NEURONS; MICE; INHIBITION; BLOCKERS;
Keywords:
ADENOSINE A(1) RECEPTORS; R-PIA [(-)-N-6-(2-PHENYLISOPROPYL)-ADENOSINE]; ATP-SENSITIVE K+; SULFONYLUREAS; CROMAKALIM; ANTINOCICEPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Ocana e J.M. Baeyens, "ROLE OF ATP-SENSITIVE K-PIA, AN ADENOSINE A(1) RECEPTOR AGONIST( CHANNELS IN ANTINOCICEPTION INDUCED BY R)", Naunyn-Schmiedeberg's archives of pharmacology, 350(1), 1994, pp. 57-62

Abstract

The influence of several K+ channel-acting drugs on antinociception induced by the adenosine A(1) receptor agonist (-)-N-6-(2-phenylisopropyl)-adenosine (R-PLA) was evaluated with a tail flick test in mice. The subcutaneous administration of R-PIA (0.5-8 mg/kg) induced a dose-dependent antinociceptive effect. The ATP-sensitive K+ (K-ATP) channel blocker gliquidone (2-8 mu g/mouse, i.c.v.) produced a dose-dependent displacement to the right of the R-PIA dose-response line, whereas the K-ATP channel opener cromakalim (32 mu g/mouse, i.c.v.) shifted it to the left. Several K-ATP channel blockers dose-dependently antagonized the antinociceptive effect of R-PIA, the order of potency being gliquidone> glipizide > glibenclamide (i.e., the same order of potency shownby these drugs in blocking K-ATP channels in neurons). In contrast, the K+ channel blockers 4-aminopyridine and tetraethylammonium did not antagonize the effect of R-PIA. These data suggest that antinociception produced by adenosine A(1) receptor agonists is mediated by the opening of ATP-sensitive K+ channels. The present results, together with those of previous studies, further support a role for K+ channel opening in the antinociceptive effect of agonists of receptors coupled to G(i)/G(o), proteins.

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Documento generato il 04/07/20 alle ore 05:27:33