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Titolo:
ACTIVITY OF TRYPTOPHAN-HYDROXYLASE AND CONTENT OF INDOLEAMINES IN DISCRETE BRAIN-REGIONS AFTER A LONG-TERM HYPOXIC EXPOSURE IN THE RAT
Autore:
PONCET L; DENOROY L; DALMAZ Y; PEQUIGNOT JM;
Indirizzi:
UNIV LYON 1,LAB NEUROPHARMACOL & NEUROCHIM,8 AVE ROCKEFELLER F-69373 LYON 08 FRANCE UNIV LYON 1,DEPT EXPT MED,INSERM,U52,CNRS ERS 5645 F-69008 LYON FRANCE UNIV LYON 1,LAB NEUROPHARMACOL & NEUROCHEM,INSERM,CJF 95 06 F-69008 LYON FRANCE UNIV LYON 1,LAB PHYSIOL REGULAT METAB CELLULAIRES & MOL,CNRS UMR 5778F-69008 LYON FRANCE
Titolo Testata:
Brain research
fascicolo: 1, volume: 765, anno: 1997,
pagine: 122 - 128
SICI:
0006-8993(1997)765:1<122:AOTACO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; DORSAL RAPHE NUCLEUS; SEROTONERGIC PROJECTIONS; ELECTRICAL-STIMULATION; VENTROLATERAL MEDULLA; RESPIRATORY RHYTHM; HYPOBARIC HYPOXIA; BLOOD-PRESSURE; NODOSE GANGLIA; NERVE ACTIVITY;
Keywords:
HYPOXIA; RAT; CHEMOREFLEX; INDOLEAMINE; TRYPTOPHAN HYDROXYLASE; NSD 1015;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L. Poncet et al., "ACTIVITY OF TRYPTOPHAN-HYDROXYLASE AND CONTENT OF INDOLEAMINES IN DISCRETE BRAIN-REGIONS AFTER A LONG-TERM HYPOXIC EXPOSURE IN THE RAT", Brain research, 765(1), 1997, pp. 122-128

Abstract

The influence of long-term hypoxia (10% O-2, 14 days) on in vivo activity of tryptophan hydroxylase and on 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentration in discrete brain regions of rats was assessed. The activity of tryptophan hydroxylase was determined through 5-hydroxytryptophan accumulation (5-HTPacc) following the administration of NSD 1015. The 5-HTPacc was significantly decreased in the dorsal and median raphe (56 and 42%, respectively) and inthe striatum (62%). Both 5-HTPacc and the ratio of the concentrationsof 5-HIAA to 5-HT were decreased in the nucleus raphe magnus (46 and 27%, respectively), the dorsomedian medulla oblongata (52 and 51%), the locus coeruleus (62 and 40%) and the anterior hypothalamic nucleus (30 and 50%). In contrast, 5-HTPacc was increased in the ventrolateral medulla oblongata (55%) and the preoptic area (83%), but the 5-HIAA/5-HT ratio was lower in these two regions. Finally, 5-HIAA/5-HT ratio was also decreased in the periventricular nucleus and in the frontal cortex. Since various patterns of variations in 5-HTPace and in 5-HIAA/5-HT ratio were observed, the factors affecting serotonin metabolism in hypoxic rats can be different among brain regions. These results show that, in the rat, long-term hypoxia induces changes in in vivo activity of tryptophan hydroxylase and in 5-HT and 5-HLAA content of some brain structures; some of these biochemical changes may be linked to adaptative mechanisms. (C) 1997 Elsevier Science B.V.

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Documento generato il 06/04/20 alle ore 06:52:30