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Titolo:
PLATELET-ACTIVATING-FACTOR MEDIATES ANGIOTENSIN-II-INDUCED PROTEINURIA IN ISOLATED-PERFUSED RAT-KIDNEY
Autore:
PERICO N; LAPINSKI R; KONOPKA K; AIELLO S; NORIS M; REMUZZI G;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA GAVAZZENI 11 I-24125 BERGAMO ITALY OSPED RIUNITI BERGAMO,DIV NEPHROL & DIALYSIS I-24100 BERGAMO ITALY
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 9, volume: 8, anno: 1997,
pagine: 1391 - 1398
SICI:
1046-6673(1997)8:9<1391:PMAP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; RANDOMIZED CONTROLLED TRIAL; LIMITS GLOMERULAR INJURY; CHRONIC-RENAL-FAILURE; DIABETIC NEPHROPATHY; RECEPTOR BLOCKADE; ENDOTHELIAL-CELLS; MESANGIAL CELLS; PERMSELECTIVITY; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
N. Perico et al., "PLATELET-ACTIVATING-FACTOR MEDIATES ANGIOTENSIN-II-INDUCED PROTEINURIA IN ISOLATED-PERFUSED RAT-KIDNEY", Journal of the American Society of Nephrology, 8(9), 1997, pp. 1391-1398

Abstract

Isolated kidney preparations (IPK) from male Sprague Dawley rats perfused at constant pressure were used to evaluate the effect of angiotensin II (AII) and platelet-activating factor (PAF) on renal function and urinary protein excretion. Compared with basal, intrarenal infusion of AII at 8 ng/min caused a progressive increase in protein excretion (11 +/- 6 versus 73 +/- 21 mu g/min) in parallel with a decline in renal perfusate flow (RPF) (29 +/- 3 versus 18 +/- 3 ml/min). Addition tothe perfusate of PAF at 50 nM final concentration also induced proteinuria (9 +/- 4 versus 55 +/- 14 mu g/min) but did not change RPF (29 +/- 3 versus 30 +/- 3 ml/min). Preexposure of isolated kidneys to the PAF receptor antagonist WEB 2086 prevented the increase in urinary protein excretion induced by AII infusion (basal: 13 +/- 6; post-AII: 12 +/- 7 mu g/min) but failed to prevent the vasoactive effect of AII (RPF, basal: 30 +/- 2; post-AII: 21 +/- 3 ml/min). In additional experiments, dexamethasone reduced the proteinuric effect of PAF remarkably. These results indicate that in isolated kidney preparation: (I) AII infusion induced proteinuria and decreased RPF; and (2) the effect of AII in enhancing urinary protein excretion was completely prevented by a specific PAF receptor antagonist, which, however, did not influence theAII-induced fall in RPF. It is suggested that PAF plays a major role in AII-induced changes in the permselective function of the glomerularcapillary barrier.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:09:06