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Titolo:
DYSTROPHIC AXONAL SWELLINGS DEVELOP AS A FUNCTION OF AGE AND DIABETESIN HUMAN DORSAL-ROOT GANGLIA
Autore:
SCHMIDT RE; DORSEY D; PARVIN CA; BEAUDET LN; PLURAD SB; ROTH KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,BOX 8118,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DIV LAB MED ST LOUIS MO 63110
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 9, volume: 56, anno: 1997,
pagine: 1028 - 1043
SICI:
0022-3069(1997)56:9<1028:DASDAA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC AUTONOMIC GANGLIA; PERIPHERAL-NERVE INJURY; GROWTH-FACTOR RECEPTOR; NEUROAXONAL DYSTROPHY; NEUROPATHIC PAIN; SENSORY NEURONS; SCHWANN-CELLS; RAT; EXPRESSION; AXOTOMY;
Keywords:
AGING; DIABETES; DORSAL ROOT GANGLIA; SENSORY NEUROPATHY; NEUROAXONAL DYSTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Schmidt et al., "DYSTROPHIC AXONAL SWELLINGS DEVELOP AS A FUNCTION OF AGE AND DIABETESIN HUMAN DORSAL-ROOT GANGLIA", Journal of neuropathology and experimental neurology, 56(9), 1997, pp. 1028-1043

Abstract

Neuroaxonal dystrophy, characterized by swollen axon terminals and, to a lesser degree, enlarged initial segments of axons or perikaryal projections, develops in human dorsal root sensory ganglia as a functionof aging and diabetes. Lesions are typically located within the satellite cell capsule and are intimately applied to sensory neuronal perikarya, which are compressed and distorted but are otherwise normal. Swollen axons contain large numbers of neurofilaments that are immunoreactive with antisera to highly phosphorylated neurofilament epitopes butfail to stain with antisera directed against hypophosphorylated neurofilament epitopes. Other dystrophic swellings contain collections of tubulovesicular profiles admired with neurotransmitter granules. Neuroaxonal dystrophy involves subpopulations of intraganglionic axons and apparent terminals, notably those containing CORP while apparently sparing others, including noradrenergic sympathetic axons. Diabetic subjects develop lesions prematurely and in greater numbers than in aged subjects. Individual dystrophic axons in diabetics and aged human subjects are identical in their light microscopic, immunohistochemical and ultrastructural appearance, suggesting the possibility of shared pathogenetic mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:18:40