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Titolo:
ABNORMAL CIRCADIAN BLOOD-PRESSURE CHANGES IN PATIENTS WITH ACUTE CEREBROVASCULAR DISORDERS
Autore:
WANG TL; CHIANG FT; HSU KL; TSENG CD; LEE TK; TSENG YZ;
Indirizzi:
NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED,7 CHUNG SHAN S RD TAIPEI 100 TAIWAN NATL TAIWAN UNIV HOSP,DEPT INTERNAL MED TAIPEI 100 TAIWAN SHIN KONG WU HO SU MEM HOSP,DEPT EMERGENCY MED TAIPEI TAIWAN
Titolo Testata:
Journal of the Formosan Medical Association
fascicolo: 9, volume: 96, anno: 1997,
pagine: 710 - 717
SICI:
0929-6646(1997)96:9<710:ACBCIP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULAR CORTEX STIMULATION; CORONARY HEART-DISEASE; ESSENTIAL-HYPERTENSION; CARDIAC-ARRHYTHMIAS; BRAIN INFARCTION; SUDDEN-DEATH; STROKE; NOREPINEPHRINE; CATECHOLAMINE; PITUITARY;
Keywords:
CIRCADIAN RHYTHM; CEREBROVASCULAR DISORDER; BLOOD PRESSURE MONITORS; HYPOTHALAMUS; AUTONOMIC NERVOUS SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Wang et al., "ABNORMAL CIRCADIAN BLOOD-PRESSURE CHANGES IN PATIENTS WITH ACUTE CEREBROVASCULAR DISORDERS", Journal of the Formosan Medical Association, 96(9), 1997, pp. 710-717

Abstract

The central neural mechanisms of circadian rhythm are well known in animal models but less so in humans. In this study we looked for correlations between abnormalities of circadian rhythm and the sites of stroke, with the aim of identifying the location regulating the circadian rhythm in humans. We investigated the circadian profiles of arterial pressure in 100 stroke patients by ambulatory blood pressure monitoringwithin 2 days after their first stroke. Patients also underwent braincomputed tomography and measurements of plasma norepinephrine and adrenal hormones. A total of 52 patients (group A) had abnormal patterns of circadian blood pressure rhythm while 48 patients had normal patterns (group N). The risk of an abnormal 24-hour blood pressure pattern was strongly inversely correlated with the distance between the lesion and the hypothalamus. There was a close positive correlation between the distance from the lesion to the hypothalamus and the circadian indices of arterial blood pressure (systolic and diastolic pressures) in both groups. Abnormal circadian changes in adrenal hormones were found in 30 of 52 patients in group A, and in nine of 48 patients in group N. Apparently, the circadian rhythm of blood pressure is modulated mainly by direct neural effects and partly by the hormonal effects of the hypothalamus and its associated neural pathways. Individualized antihypertensive treatment and additional monitoring for possible cardiac events should be performed for those at a high risk of autonomic dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:13:58