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Titolo:
INFLUENZA, A SPECIAL FORM OF A ZOONOSIS
Autore:
ROTT R;
Indirizzi:
UNIV GIESSEN,INST VIROL,FRANKFURTER STR 107 D-35392 GIESSEN GERMANY
Titolo Testata:
Berliner und Munchener Tierarztliche Wochenschrift
fascicolo: 7-8, volume: 110, anno: 1997,
pagine: 241 - 246
SICI:
0005-9366(1997)110:7-8<241:IASFOA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
GER
Soggetto:
VIRUS; PATHOGENICITY; CLEAVAGE; H1N1; H3N2;
Keywords:
INFLUENZA; INFLUENZA VIRUSES; VIRUS HEMAGGLUTININ; HOST RANGE; EVOLUTION AND PATHOGENICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R. Rott, "INFLUENZA, A SPECIAL FORM OF A ZOONOSIS", Berliner und Munchener Tierarztliche Wochenschrift, 110(7-8), 1997, pp. 241-246

Abstract

Findings based on molecular genetics and phylogeny indicate that avian species represent an important reservoir for influenza viruses and that virus strains of man and different mammals originated from avian influenza virus ancestors. In contrast to infectious agents causing classical zoonoses, influenza viruses have to alter their genetic make upin order to change their host range. The special, segmented structureof the viral RNA allows an exchange of gene(s) between two different influenza viruses (reassortment) resulting in viruses with different combinations of genome segments and thereby coating new biological properties. Under the selective pressure of the new host the most adapted virus variants will succeed which arose from a genetically heterogenous virus population with additional mutations. In particular mutations of the genes encoding the polymerase complex (mutator mutations) wouldbe advantageous for rapid adaptation in a hostile environment. The generation of influenza viruses capable of overcoming the species barrier is a rare event since only virus variants will succeed which are genetically stable and transmissible and which replicate efficiently in the new host. It is considered likely that pigs act as intermediate hosts for adaptation of avian viruses to man.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:25:28