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Titolo:
COMPARISON OF OXIDATION-PRODUCTS FROM DNA COMPONENTS BY GAMMA-IRRADIATION AND FENTON-TYPE REACTIONS
Autore:
MURATAKAMIYA N; KAMIYA H; MURAOKA M; KAJI H; KASAI H;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM ONCOL,YAHATANISHI KU,1-1 ISEIGAOKA KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM ONCOL,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT HLTH POLICY & MANAGEMENT,YAHATANISHI KU KITAKYUSHU FUKUOKA 807 JAPAN JAPAN WOMENS UNIV,FAC SCI,DEPT CHEM & BIOL SCI,BUNKYO KU TOKYO 112 JAPAN
Titolo Testata:
Journal of radiation research
fascicolo: 2, volume: 38, anno: 1997,
pagine: 121 - 131
SICI:
0449-3060(1997)38:2<121:COOFDC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-HA-RAS; FERRIC NITRILOTRIACETATE; IN-VITRO; 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE; OPPOSITE 2-HYDROXYADENINE; DEOXYRIBONUCLEIC-ACID; IONIZING-RADIATION; SEQUENCE CONTEXTS; AQUEOUS-SOLUTION; HOT-SPOTS;
Keywords:
REACTIVE OXYGEN SPECIES; GAMMA-IRRADIATION; FENTON-TYPE REACTION; OXIDATIVE BASE DAMAGE; GLYOXAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N. Muratakamiya et al., "COMPARISON OF OXIDATION-PRODUCTS FROM DNA COMPONENTS BY GAMMA-IRRADIATION AND FENTON-TYPE REACTIONS", Journal of radiation research, 38(2), 1997, pp. 121-131

Abstract

The four 2'-deoxyribonucleosides were gamma-irradiated or were aerobically treated with Fenton-type-reagents, Fe(II)-EDTA or a renal carcinogen Fe(II)-nitrilotriacetic acid (NTA) under the neutral conditions. The reaction mixtures were immediately analyzed by reverse-phase HPLC. Major products detected were 2-hydroxydeoxyadenosine (2-OH-dA), 8,5'-cyclodeoxyadenosine (cyclo-dA), 8-hydroxydeoxyadenosine (8-OH-dA), 5-formyldeoxyuridine (5-CHO-dU), 5-hydroxydeoxycytidine (5-OH-dC), 8-hydroxydeoxyguanosine (8-OH-dG), 8,5'-cyclodeoxyguanosine (cyclo-dG), and glyoxal and its adduct with dG. Ratio of these oxidized products were dramatically changed depending upon the agents used. For example, 2-OH-dA was a modified nucleoside produced most efficiently by Fe(II)-EDTA, while 5-CHO-dU and 5-OH-dC were the major products by the Fe(II)-NTAtreatment and gamma-irradiation, respectively. Glyoxal itself was estimated to be produced most frequently (13 folds of 8-OH-dG) when treated with Fe(II)-EDTA, but its formation was not detected by the treatment with Fe(II)-NTA or by gamma-irradiation. 8-OH-dA was not produced by Fe-EDTA or Fe-NTA but was produced by gamma-irradiation. In contrast, 2-OH-dA was not produced by gamma-irradiation. These results suggestthat triphosphates of 2-OH-dA, cyclo-dA, 8-OH-dA, cyclo-dG, 5-CHO-dU,5-OH-dC, and glyoxal-dG as well as 8-OH-dG may be produced in cells with different ratio by various types of oxidative stress and involved in mutagenesis and carcinogenesis.

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Documento generato il 12/07/20 alle ore 06:45:43