Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MODULATION OF ANTIGEN-PROCESSING AND PRESENTATION BY PERSISTENT VIRUS-INFECTIONS AND IN TUMORS
Autore:
EHRLICH R;
Indirizzi:
TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT CELL RES & IMMUNOL IL-69978 RAMAT AVIV ISRAEL
Titolo Testata:
Human immunology
fascicolo: 2, volume: 54, anno: 1997,
pagine: 104 - 116
SICI:
0198-8859(1997)54:2<104:MOAAPB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MHC CLASS-I; EPSTEIN-BARR-VIRUS; CYTOTOXIC T-LYMPHOCYTES; HIGHLY ONCOGENIC ADENOVIRUS-12; CERVICAL INTRAEPITHELIAL NEOPLASIA; CELLULAR IMMUNE-RESPONSES; TRANSFORMED RAT-CELLS; HIV-1 NEF PROTEIN; DOWN-REGULATION; HUMAN CYTOMEGALOVIRUS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
R. Ehrlich, "MODULATION OF ANTIGEN-PROCESSING AND PRESENTATION BY PERSISTENT VIRUS-INFECTIONS AND IN TUMORS", Human immunology, 54(2), 1997, pp. 104-116

Abstract

Cell-mediated immunity is effective against cells harboring active virus replication and is critical for the elimination of ongoing infections, opposing tumor progression, and reducing or preventing the reactivation of persistent viruses and tumor metastasis. The capacity of persistent viruses and tumor cells to maintain a long-term relationship with their host presupposes mechanisms for circumventing antiviral or antitumor defenses. By suppressing the expression of molecules associated with antigen processing and presentation, abrogation of the major immune mechanism that deals with the elimination of infected and transformed cells is achieved. This is accomplished in tumors predominantly by transcriptional downregulation of genes encoding class I major histocompatibility complex antigens, peptide transporter molecules, and the proteasome-associated low molecular mass protease subunits, and in cells expressing viral proteins by interfering with peptide transport and the assembly/transport of class I complexes. In addition, virus-infected cells and selected tumor cells express mainly nonimmunogenic or antagonistic peptide epitopes. This review describes mechanisms used by viruses and in transformed cells for interference with antigen processing and presentation and addresses their significance for in vivo viral persistence and tumor progression. (C) American Society for Histocompatibility and Immunogenetics, 1997.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:34:39