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Titolo:
DOPAMINE DEPRESSES EXCITATORY AND INHIBITORY SYNAPTIC TRANSMISSION BYDISTINCT MECHANISMS IN THE NUCLEUS-ACCUMBENS
Autore:
NICOLA SM; MALENKA RC;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT,LPPI,BOX 0984 SAN FRANCISCO CA94143 UNIV CALIF SAN FRANCISCO,DEPT PSYCHIAT,LPPI SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT NEUROBIOL ADDICT SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,GRAD PROGRAM NEUROSCI SAN FRANCISCO CA 94143
Titolo Testata:
The Journal of neuroscience
fascicolo: 15, volume: 17, anno: 1997,
pagine: 5697 - 5710
SICI:
0270-6474(1997)17:15<5697:DDEAIS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED-PULSE FACILITATION; GAMMA-AMINOBUTYRIC-ACID; PRESYNAPTIC INHIBITION; NEURONS INVITRO; IDENTIFIED NEURONS; ADENYLATE-CYCLASE; RAT-BRAIN; IN-VITRO; ULTRASTRUCTURAL-LOCALIZATION; TYROSINE-HYDROXYLASE;
Keywords:
AMPHETAMINE; COCAINE; DOPAMINE; MINIATURE INHIBITORY POSTSYNAPTIC CURRENTS; MINIATURE EXCITATORY POSTSYNAPTIC CURRENTS; NUCLEUS ACCUMBENS; PRESYNAPTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Nicola e R.C. Malenka, "DOPAMINE DEPRESSES EXCITATORY AND INHIBITORY SYNAPTIC TRANSMISSION BYDISTINCT MECHANISMS IN THE NUCLEUS-ACCUMBENS", The Journal of neuroscience, 17(15), 1997, pp. 5697-5710

Abstract

The release of dopamine (DA) in the nucleus accumbens (NAc) is thought to be critical for mediating natural rewards as well as for the reinforcing actions of drugs of abuse. DA and amphetamine depress both excitatory and inhibitory synaptic transmission in the NAc by a presynaptic D1-like DA receptor. However, the mechanisms of depression of excitatory and inhibitory synaptic transmission appear to be different. DA depressed the frequency of spontaneous miniature EPSCs, but the frequency of miniature IPSCs was depressed only when spontaneous release wasmade dependent on Ca2+ influx through voltage-dependent Ca2+ channels. Furthermore, the K+ channel blocker Ba2+ attenuated the effects of DA on evoked IPSPs, but not on EPSPs. Thus, DA appears to depress inhibitory synaptic transmission in the NAc by reducing Ca2+ influx into the presynaptic terminal, but depresses excitatory transmission by a distinct mechanism that is independent of the entry of Ca2+.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:30:03