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Titolo:
QUANTAL NEUROTRANSMITTER SECRETION RATE EXHIBITS FRACTAL BEHAVIOR
Autore:
LOWEN SB; CASH SS; POO MM; TEICH MC;
Indirizzi:
BOSTON UNIV,DEPT ELECT & COMP ENGN,BIOMED ENGN & COGNIT & NEURAL SYSTBOSTON MA 02215 BOSTON UNIV,DEPT ELECT & COMP ENGN,BIOMED ENGN & COGNIT & NEURAL SYSTBOSTON MA 02215 COLUMBIA UNIV,DEPT BIOL SCI NEW YORK NY 10027 UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093
Titolo Testata:
The Journal of neuroscience
fascicolo: 15, volume: 17, anno: 1997,
pagine: 5666 - 5677
SICI:
0270-6474(1997)17:15<5666:QNSREF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROMUSCULAR SYNAPSE; TRANSMITTER SECRETION; RENEWAL PROCESSES; POINT-PROCESSES; ION CHANNELS; SPIKE TRAINS; ACETYLCHOLINE; NEURONS; RELEASE; NOISE;
Keywords:
QUANTAL SECRETION; VESICULAR EXOCYTOSIS; MINIATURE END-PLATE CURRENTS; FRACTAL; LONG-TERM CORRELATION; LOGNORMAL PROCESS; XENOPUS NEUROMUSCULAR JUNCTION; MYOCYTE AUTORECEPTION; FIBROBLAST; HIPPOCAMPAL SYNAPSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
S.B. Lowen et al., "QUANTAL NEUROTRANSMITTER SECRETION RATE EXHIBITS FRACTAL BEHAVIOR", The Journal of neuroscience, 17(15), 1997, pp. 5666-5677

Abstract

The rats of exocytic events from both neurons and nonneuronal cells exhibits fluctuations consistent with fractal (self-similar) behavior in time, as evidenced by a number of statistical measures. We explicitly demonstrate this for neurotransmitter Secretion at Xenopus neuromuscular junctions and for rat hippocampal synapses in culture; the exocytosis of exogenously supplied neurotransmitter from cultured Xenopus myocytes and from rat fibroblasts behaves similarly, The magnitude of the fluctuations of the rate of exocytic events about the mean decreasesslowly as the rate is computed over longer and longer time periods, the periodogram decreases in power-law manner with frequency, and the Allan factor (relative variance of the number of exocytic events) increases as a power-law function of the counting time. These features are hallmarks of self-similar behavior. Their description requires models that exhibit long-range correlation(memory] in event occurrences, Mle have developed a physiologically plausible model that accords with ailof the statistical measures that we have examined, The appearance of fractal behavior at synapses, as well as in systems comprising collections of synapses, indicates that such behavior is ubiquitous in neuralsignaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:27:13