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Titolo:
CLONING, CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF THE HUMAN ADENOSINE A3 RECEPTOR (ADORA3) GENE
Autore:
ATKINSON MR; TOWNSENDNICHOLSON A; NICHOLL JK; SUTHERLAND GR; SCHOFIELD PR;
Indirizzi:
ST VINCENTS HOSP,GARVAN INST MED RES,384 VICTORIA ST DARLINGHURST NSW2010 AUSTRALIA ST VINCENTS HOSP,GARVAN INST MED RES DARLINGHURST NSW 2010 AUSTRALIA WOMENS & CHILDRENS HOSP,DEPT CYTOGENET & MOL GENET,CTR GENET MED ADELAIDE SA 5006 AUSTRALIA
Titolo Testata:
Neuroscience research
fascicolo: 1, volume: 29, anno: 1997,
pagine: 73 - 79
SICI:
0168-0102(1997)29:1<73:CCACAO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; HUMAN BRAIN; EXPRESSION; RAT; LOCALIZATION; CELLS; CDNA;
Keywords:
1P13.3; CHROMOSOMAL LOCALIZATION; ADENOSINE A3 RECEPTOR; ADORA3; GENE STRUCTURE; MESSENGER-RNA EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Atkinson et al., "CLONING, CHARACTERIZATION AND CHROMOSOMAL ASSIGNMENT OF THE HUMAN ADENOSINE A3 RECEPTOR (ADORA3) GENE", Neuroscience research, 29(1), 1997, pp. 73-79

Abstract

The gene for the inhibitory G-protein coupled human A3 adenosine receptor (ADORA3) was isolated and sequence analysis shows that the codingregion is interrupted by a single intron of size 2.4 kb. The locationof this intron in the second intracellular loop is conserved with respect to the A1, A2a and A2b adenosine receptor subtype genes. The ADORA3 gene was mapped to 1p13.3 by fluorescence in situ hybridisation. Northern blot studies show that the gene is widely expressed and is mostabundant in brain and some endocrine tissues. We have mapped multipletranscription start sites in two cell lines and lung tissue by primerextension and 5' RACE (rapid amplification of cDNA ends). The ADORA3 gene promoter lacks CAAT and TATA boxes but has putative binding sitesfor multiple transcription factors. In contrast to the Al adenosine receptor gene we find no evidence of alternate splicing in the 5' untranslated region of the ADORA3 gene. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:20:01