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Titolo:
FETAL CEREBRAL OXYGENATION AND HEMODYNAMICS DURING LABOR MEASURED BY NEAR-INFRARED SPECTROSCOPY
Autore:
PEEBLES DM; OBRIEN P;
Indirizzi:
UNIV COLL LONDON,SCH MED,DEPT OBSTET & GYNAECOL,89-96 CHENIES MEWS LONDON WC1E 6HX ENGLAND
Titolo Testata:
Mental retardation and developmental disabilities research reviews
fascicolo: 1, volume: 3, anno: 1997,
pagine: 59 - 68
SICI:
1080-4013(1997)3:1<59:FCOAHD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; OPTICAL PATHLENGTH; NEWBORN-INFANTS; DELIVERY; HEMOGLOBIN; ASPHYXIA; FOREARM; VOLUME; SHEEP; PALSY;
Keywords:
NEAR-INFRARED SPECTROSCOPY; INTRAPARTUM FETAL SURVEILLANCE; CEREBRAL OXYGENATION AND HEMODYNAMICS; INTRAPARTUM HYPOXIA-ISCHEMIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Peebles e P. Obrien, "FETAL CEREBRAL OXYGENATION AND HEMODYNAMICS DURING LABOR MEASURED BY NEAR-INFRARED SPECTROSCOPY", Mental retardation and developmental disabilities research reviews, 3(1), 1997, pp. 59-68

Abstract

The failure of modern fetal monitoring techniques to measure either oxygenation or perfusion within the fetal brain may underlie their poorspecificity in the detection of intrapartum hypoxia-ischaemia. We have adapted the technique of near-infrared spectroscopy (NIRS) to obtaincontinuous, quantified measurements of changes in human fetal cerebral oxygenation and blood volume during labour. More than 140 fetuses have been studied at University College London for periods ranging from 10 to 765 minutes. Reciprocal changes in the cerebral concentrations of oxyhemoglobin and deoxyhemoglobin, indicating changing cerebral haemoglobin saturation, have been observed during uterine hyperstimulationwith oxytocin, administration of maternal oxygen, changing maternal posture, and late fetal heart rate decelerations. Uterine contraction frequency greater than 1 every 2 minutes was associated with a fall in fetal cerebral oxygenation. A method for quantifying the oxygen saturation of hemoglobin derived from all vascular compartments (SmcO(2)) isdescribed. There was a significant positive correlation between SmcO(2) and umbilical artery pH. Conversely, the base deficit of blood fromthe umbilical artery showed a negative correlation with SmcO(2). Changes in optical pathlength due to probe movement during uterine contractions are a potential source of error in the measurements. Preliminarydata obtained using intensity modulated optical spectrometry, a technique that continuously measures optical pathlength, suggest that the maximum contribution of movement artifact to observed changes in chromophore concentration is 12%. These preliminary data demonstrate that NIRS is capable of measuring fetal cerebral oxygenation and blood volumeduring labour. However, because none of the fetuses in this study wasborn with evidence of intrapartum hypoxia-ischaemia, we cannot comment on the value of NIRS as a means of intrapartum surveillance. Furtherdevelopments, including the routine use of IMOS and rigorous testing by randomized trials, will be required before this question is answered. (C) 1997 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:47:59